Abstract
In Behçet's disease (BD), there is a marked increase in vascular complications. Approximately 30% of patients with BD suffer from thrombosis of the arteries and veins, varices, aneurysms, and thrombophlebitis of superficial or deep veins. Protein C and Protein S are major inhibitors of coagulation, and it is well known that the deficiency of Protein C and Protein S causes thrombotic disorders. Protein C and Protein S activities were measured in 23 patients with BD and in a control group consisting of 23 age- and sex-matched healthy volunteers. Patients who had received anticoagulant or oral contraceptive drugs, or who had liver disease or active thrombosis, were not included in the study. Of the 23 patients with BD (age, 13-55 years), the mean Protein S activities (94.2 +/- 11.3%) were slightly lower than the means of the control group (109.1 +/- 8.4%), but not statistically significant differences could be demonstrated (p > 0.05). Compared with the means of the control group (103.5 +/- 6.9%), the Protein C activities were not lower in BD (106.3 +/- 8.4%). No statistical difference was determined. Protein C and Protein S deficiencies are not a probable cause of thrombotic manifestations in BD. We do not recommend the measuremen...Continue Reading
Citations
Jul 20, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ali YalçındağNamık Delibaş
Apr 18, 2002·Thrombosis Research·Sedat KirazMeral Calgüneri
Apr 3, 2010·The Open Cardiovascular Medicine Journal·Micaela La ReginaDomenico Prisco
Apr 25, 2012·ISRN Pharmacology·M B Owlia, G Mehrpoor
Aug 4, 2004·British Journal of Haematology·Silvia NavarroFrancisco España
Apr 18, 2015·Thrombosis Journal·Giacomo EmmiDomenico Prisco
Jan 29, 2002·The American Journal of Medicine·Gerard EspinosaJoan-Carles Reverter
Dec 29, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·M Cem ArHasan Yazici
Mar 3, 2009·International Journal of Cancer. Journal International Du Cancer·Lindsay M MortonJames V Lacey
Apr 13, 2010·Clinical Rheumatology·N Şule YaşarCengiz Korkmaz
Mar 24, 2000·Journal of Clinical Gastroenterology·Y BayraktarD H Van Thiel
Aug 26, 1999·Current Opinion in Pulmonary Medicine·F Erkan
Jul 10, 2001·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·R Bick
Jul 29, 2000·Seminars in Pediatric Neurology·N F Schor
Sep 6, 2013·Thrombosis Journal·Hoda Abdel BadaeeGaafar Ragab