PMID: 9436795Jan 22, 1998Paper

Protein C and S deficiency in children with ischemic cerebrovascular accident

Pediatric Neurology
S Koh, L S Chen

Abstract

A prothrombotic state caused by a deficiency of protein C or protein S, each an inhibitor of coagulation cascade, increases the risk of ischemic cerebrovascular accident (ICVA) in young adults. This retrospective review studies the relationship of protein C or S deficiency with childhood ICVA. From 1989 to 1995, 37 children were diagnosed by neuroimaging with ICVA unrelated to any known preexisting diagnosis. Protein C deficiency or protein S deficiency was the only identified risk factor for 5.4% (2 patients) and 13.5% (5 patients), respectively, of these 37 children. The data suggest that protein C or protein S deficiency is an important risk factor of ICVA in children.

References

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Citations

Mar 20, 2002·Current Neurology and Neuroscience Reports·B H BendixenR Lango
May 20, 2006·Thrombosis Research·Rod W Hunt, Terrie E Inder
Mar 23, 2005·Archives of Disease in Childhood·S HaywoodV Ganesan
Sep 20, 2002·AJR. American Journal of Roentgenology·Athos D PatsalidesNicholas J Patronas
Jan 22, 2011·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Anil SachdevDhiren Gupta
May 7, 2004·Current Problems in Pediatric and Adolescent Health Care·Deepa Bhojwani, David Hart

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