PMID: 1201618Dec 1, 1975Paper

Protein chain initiation in vitro by liver cell components from DMNA-treated rats

Chemico-biological Interactions
O Nygård, T Hultin

Abstract

The mechanism of inhibition of protein synthesis in rat liver after dimethylnitrosamine (DMNA) administration was studied at the level of peptide-chain initiation by use of initiation-dependent amino acid incorporating systems. Ribosomal monomers, poly(A)-concontaining loss of acticity due to the DMNA treatment. The poly(A) RNA from monosomes and polysomes, and crude initiation factors from microsomes were prepared 2 h after a single dose of DMNA (75 mg/kg), and their activities in the production of new protein chains determined under conditions of nearly linear response. Monosomes and crude initiation factors from DMNA-treated rats were at least as active as those from controls. Preparations of poly(A)-containing RNA had a consistently higher template activity when prepared from polysomes instead of monosomes. However, in neither case was there any ltaining RNA was methylated by DMNA to about the same extent as the 18S and 28S rRNA. The methylation was consistently somewhat higher in the RNA preparations from monosomes than in those from polysomes.

References

Jul 13, 1973·Biochimica Et Biophysica Acta·I FaifermanM E Kaighn
Oct 25, 1974·Journal of Molecular Biology·C Milcarek, S Penman
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M H Schreier, T Staehelin
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M Reichman, S Penman
Apr 1, 1973·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A Delpino, U Ferrini
May 1, 1972·Experimental Cell Research·M O Nilsson, T Hultin
Nov 1, 1967·The Biochemical Journal·S Villa-Treviño
May 1, 1969·Experimental Cell Research·T HultinM O Nilsson

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Citations

Jul 1, 1981·Chemico-biological Interactions·A DelpinoU Ferrini
Jan 1, 1976·Preparative Biochemistry·O Nygård, T Hultin
Apr 1, 1978·Chemico-biological Interactions·T HultinA Von der Decken
Jul 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A Delpino, U Ferrini

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