Protein corona of nanoparticles: distinct proteins regulate the cellular uptake

Biomacromolecules
Sandra RitzVolker Mailänder

Abstract

Understanding nanoparticle-protein interactions is a crucial issue in the development of targeted nanomaterial delivery. Besides unraveling the composition of the nanoparticle's protein coronas, distinct proteins thereof could control nanoparticle uptake into specific cell types. Here we differentially analyzed the protein corona composition on four polymeric differently functionalized nanoparticles by label-free quantitative mass spectrometry. Next, we correlated the relative abundance of identified proteins in the corona with enhanced or decreased cellular uptake of nanoparticles into human cancer and bone marrow stem cells to identify key candidates. Finally, we verified these candidate proteins by artificially decorating nanoparticles with individual proteins showing that nanoparticles precoated with the apolipoproteins ApoA4 or ApoC3 significantly decreased the cellular uptake, whereas precoating with ApoH increased the cellular uptake.

References

Nov 13, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·P ThiagarajanC R Benedict
Mar 4, 2000·International Journal of Pharmaceutics·A GessnerR H Müller
Oct 28, 2004·Thrombosis Research·Spiros MiyakisSteven A Krilis
Oct 13, 2005·Molecular & Cellular Proteomics : MCP·Jeffrey C SilvaScott J Geromanos
May 4, 2006·Molecular & Cellular Proteomics : MCP·Ralph A BradshawRuedi Aebersold
Jul 6, 2006·Analytical and Bioanalytical Chemistry·Olaf JahnHartmut D Kratzin
Feb 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tommy CedervallSara Linse
Jun 27, 2007·Angewandte Chemie·Tommy CedervallKenneth A Dawson
Sep 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Martin LundqvistKenneth A Dawson
Apr 21, 2009·Nature Methods·Jacek R WiśniewskiMatthias Mann
May 15, 2009·The FEBS Journal·Erik HellstrandTommy Cedervall
Sep 8, 2009·Nature Nanotechnology·Carlheinz RöckerG Ulrich Nienhaus
Apr 2, 2010·Journal of the American Chemical Society·Dorota WalczykKenneth A Dawson
Feb 4, 2011·Journal of the American Chemical Society·Marco P MonopoliKenneth A Dawson
Aug 25, 2011·ACS Nano·Martin LundqvistKenneth Dawson
Nov 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julia PatzigHauke Bernhard Werner
Jul 19, 2012·ACS Nano·James Chen Yong KahKimberly Hamad-Schifferli
Dec 6, 2012·Nature Nanotechnology·Marco P MonopoliKenneth A Dawson
Sep 24, 2013·Nature Nanotechnology·Stefan TenzerRoland H Stauber
Oct 17, 2013·ACS Nano·Anna Cifuentes-RiusKimberly Hamad-Schifferli
Feb 19, 2014·Materials Horizons·Krishnendu SahaVincent M Rotello
May 2, 2014·The Journal of Physical Chemistry. B·Candace C Fleischer, Christine K Payne
Jun 28, 2014·ACS Nano·Daniel F MoyanoVincent M Rotello
Jul 12, 2014·Accounts of Chemical Research·Candace C Fleischer, Christine K Payne

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Citations

Jan 20, 2016·Nanoscale·Diego EstupiñánDaniel Crespy
Jan 12, 2016·ACS Nano·Sergio Dominguez-MedinaStephan Link
Jul 19, 2015·Biochemical and Biophysical Research Communications·Bengt FadeelKunal Bhattacharya
Jan 3, 2016·The Journal of Chemical Physics·Hender Lopez, Vladimir Lobaskin
Apr 30, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Alexander S TiminAlexander A Goncharenko
Oct 28, 2015·Journal of Proteomics·Magdalena MatysiakMarcin Kruszewski
Sep 16, 2015·ACS Applied Materials & Interfaces·Alden M ClemmentsChristopher C Landry
Aug 19, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexandra C RinkenauerUlrich S Schubert
May 20, 2016·Critical Reviews in Toxicology·Ivo IavicoliGunnar Nordberg
Jun 15, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sourav Bhattacharjee
Jun 16, 2016·Angewandte Chemie·Susanne SchöttlerVolker Mailänder
Jul 19, 2016·Chemical Communications : Chem Comm·Xi GengTijana Z Grove
Jul 6, 2016·Biomacromolecules·Adva KrivitskyRonit Satchi-Fainaro
Oct 25, 2016·Future Medicinal Chemistry·Shaghayegh Fathi, Adegboyega K Oyelere
Nov 1, 2016·Nature Reviews. Nephrology·Nazila KamalyOmid C Farokhzad
Nov 12, 2016·Nature Reviews. Cancer·Jinjun ShiOmid C Farokhzad
Jan 4, 2017·Analytical Chemistry·Brad A KairdolfShuming Nie
Mar 7, 2017·Journal of the American Chemical Society·Alden M ClemmentsChristopher C Landry
Mar 16, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Francesca PederzoliBarbara Ruozi
Mar 17, 2017·Current Opinion in Biotechnology·Carolina Carrillo-CarrionWolfgang J Parak
Apr 6, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Neus FeliuWolfgang J Parak
May 20, 2017·Nanomedicine·Yazhou Wang, Guixue Wang
Jun 6, 2017·Small·Debora BonvinMarijana Mionić Ebersold
Feb 10, 2017·Journal of Tissue Engineering and Regenerative Medicine·Marta Machado-PereiraRaquel Ferreira
Jul 12, 2017·The Analyst·Debora BonvinMarijana Mionić Ebersold
May 4, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Arnold SiposEdward D Crandall

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