Protein correlates of molecular alterations in lung adenocarcinoma: Immunohistochemistry as a surrogate for molecular analysis

Seminars in Diagnostic Pathology
Lynette M Sholl

Abstract

Most clinically actionable alterations in lung adenocarcinomas are detected using molecular or cytogenetic techniques. However, many such alterations have a protein-level correlate that can be interrogated using immunohistochemistry. This review will summarize the therapeutic relevance of predictive biomarkers in lung adenocarcinoma including the oncogenes EGFR, MET, ALK, RET, and ROS1 and tumor suppressors PTEN and LKB1 with an emphasis on established and emerging protein immunohistochemistry reagents and their promise in clinical practice.

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Citations

Oct 20, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Qin ShenXiaojun Zhou
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Sep 10, 2020·BioMed Research International·Shusen ZhangZhigang Cai
Dec 27, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Theresa A BoyleUNKNOWN Lung Cancer Mutation Consortium (LCMC) Pathologist Panel Group

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