PMID: 9178115May 1, 1997Paper

Protein degradation by Prevotella intermedia and Actinomyces meyeri supports the growth of non-protein-cleaving oral bacteria in serum

Journal of Clinical Periodontology
H J Jansen, J S van der Hoeven

Abstract

The proteolytic activities of oral bacteria are thought to play an important role in the aetiology of dental abscesses. Bacteria-derived proteases may contribute to tissue destruction, and are likely to impair host defence by degrading immunoglobulins and complement. Degraded periodontal tissue and tissue fluid are likely to constitute essential sources of nutrients in the abscess. Tissue fluid, which is derived from serum, is rich in protein and poor in carbohydrate, suggesting that breakdown of protein and fermentation of amino acids is a crucial step to generate energy for growth of the microflora. The number of oral bacterial species that perform hydrolytic cleavage of protein into polypeptides, the first step in protein degradation, is relatively small compared to the large majority of peptidase-producing species. In this study, we therefore investigated the growth-promoting effect of proteinase-producing species like Prevotella intermedia and Actinomyces meyeri on the growth of some non-proteinase producing bacteria in mixed cultures. We used serum as a substitute for the supposed natural substrate of the abscess microflora. The breakdown of serum proteins was investigated using capillary electrophoresis. Poor growth was ...Continue Reading

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Citations

Jul 6, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·S ElgünS Demirtaş
Dec 12, 2001·Journal of Clinical Periodontology·P S Langendijk-GenevauxJ S van der Hoeven
May 5, 2006·Applied and Environmental Microbiology·F DalwaiJ Pratten
Jun 6, 2007·Australian Dental Journal·D Figdor, G Sundqvist
Jan 22, 2017·Journal of Biotechnology·Szymon P SzafrańskiMeike Stiesch

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