Protein degradation in bupivacaine-treated muscles. The role of extracellular calcium

Journal of the Neurological Sciences
J H Steer, F L Mastaglia

Abstract

The time course of protein degradation and the influence of extracellular calcium and the calcium-channel blocker verapamil were investigated by measuring tyrosine release from the isolated rat soleus muscle exposed to the local anaesthetic agent bupivacaine. Degradation rates were reduced during the first 60-90 min and subsequently increased in muscles treated with bupivacaine concentrations of 1.5 mM or higher. When calcium was omitted from the incubation medium the initial reduction in degradation was greater and the subsequent increase was reduced or prevented. Overall, verapamil (10(-5)M or 10(-6)M) did not significantly alter the degree or time-course of protein degradation.

References

Apr 1, 1986·Journal of the Neurological Sciences·J H SteerI Van Bruggen
Apr 15, 1982·The Biochemical Journal·S E LewisD F Goldspink
Dec 1, 1983·Biochemical Pharmacology·R A Janis, A Scriabine
Aug 1, 1984·Biochemical Pharmacology·S Ranganathan, R L Jackson
Sep 14, 1981·Life Sciences·S Ishiura

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Citations

Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Stéphanie DuguezDamien Freyssenet
Jan 16, 2002·The Journal of Biological Chemistry·William IrwinPaolo Bernardi
Jun 7, 2003·American Journal of Physiology. Endocrinology and Metabolism·Stéphanie DuguezDamien Freyssenet
May 11, 2010·Survey of Ophthalmology·Suqin GuoMarco Zarbin

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