Protein degradation in DNA damage response

Seminars in Cell & Developmental Biology
Ilektra Kouranti, Anne Peyroche

Abstract

DNA damage is a major threat to genome integrity. To reduce its deleterious effects, cells have developed coordinated responses, collectively referred to as the "DNA damage response" pathway (DDR). In multicellular organisms, the DDR pathway has a critical role in preventing tumorigenesis, which accounts for the wide use of drugs targeting DDR factors in anti-cancer therapy. Post-translational modifications such as phosphorylation, ubiquitylation, acetylation, sumoylation are integral part of the DDR pathway. Ubiquitylation of DDR-related factors has recently emerged both as a switch initiating signaling cascades and as a proteolytic signal coordinating recruitment and disassembly of those proteins. In this review we will present evidence supporting an increasingly important role for the ubiquitin-proteasome-mediated degradation in regulating DDR at different levels.

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Citations

Apr 27, 2013·Nucleic Acids Research·Claire Concannon, Robert S Lahue
May 18, 2016·International Journal of Molecular Sciences·Viviane A O SilvaFabrice Fleury
Sep 25, 2017·International Journal of Molecular Sciences·Sentiljana GumeniIoannis P Trougakos
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May 15, 2018·The Journal of Pathology·Vassilis G GorgoulisIoannis P Trougakos
Jul 22, 2018·Scientific Reports·Florian LafontFabrice Fleury
May 2, 2020·Signal Transduction and Targeted Therapy·Rui-Xue Huang, Ping-Kun Zhou
Jun 3, 2021·International Journal of Molecular Sciences·Tingting Zou, Zhenghong Lin
Jun 25, 2021·Cell Chemical Biology·Xiaofeng JiangJames R Mitchell

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