Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteins

Annals of the New York Academy of Sciences
Stephen C Meredith

Abstract

Protein aggregation is a prominent feature of many neurodegenerative diseases, such as Alzheimer's, Huntington's, and Parkinson's diseases, as well as spongiform encephalopathies and systemic amyloidoses. These diseases are sometimes called protein misfolding diseases, but the latter term begs the question of what is the "folded" state of proteins for which normal structure and function are unknown. Amyloid consists of linear, unbranched protein or peptide fibrils of approximately 100 A diameter. These fibrils are composed of a wide variety of proteins that have no sequence homology, and no similarity in three-dimensional structures--and yet, as fibrils, they share a common secondary structure, the beta-sheet. Because of the prominence of amyloid deposits in many of these diseases, much effort has gone into elucidation of fibril structure. Recent advances in solid-state NMR spectroscopy and other biophysical techniques have led to the partial elucidation of fibril structure. Surprisingly at the time, for beta-amyloid, a set of 39-43-amino-acid peptides believed to play a pathogenic role in Alzheimer's disease, the beta-sheets are parallel with all amino acids of the sheets in-register. Since the time of those observations, howe...Continue Reading

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·E P Benditt, N Eriksen
May 1, 1992·Kidney International·K M Koch
Jan 1, 1991·Advances in Human Genetics·D R Jacobson, J N Buxbaum
Jan 31, 1991·Biochemical and Biophysical Research Communications·A E RoherA R Wakade
May 15, 1991·Biochemical and Biophysical Research Communications·R P LinkeG Rothe
Sep 30, 1985·Biochemical and Biophysical Research Communications·L H ConnorsA S Cohen
Aug 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W E KlunkD J Abraham
Jul 29, 1988·Biochemical and Biophysical Research Communications·G G CornwellP Westermark
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A RoherD KuKuruga
Jan 1, 1986·Methods in Enzymology·D J Selkoe, C R Abraham
Dec 1, 1969·Archives of Neurology·W A den Jager
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G G GlennerJ D Termine
Apr 1, 1968·The Journal of Clinical Investigation·M PrasE C Franklin
Nov 1, 1968·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·E D Eanes, G G Glenner
Sep 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·L BonarM M Skinner
Aug 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N ArispeE Rojas
Jun 28, 1994·Biochemistry·J TalafousM G Zagorski
May 1, 1995·Neurobiology of Aging·D W DicksonP Davies
Mar 1, 1995·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·D R HowlettG W Roberts
Nov 1, 1994·The Tohoku Journal of Experimental Medicine·Y Kuroda, M Kawahara
Feb 1, 1995·Current Opinion in Immunology·H GewurzT F Lint
Jun 1, 1994·Current Opinion in Neurobiology·M F Bear, R C Malenka
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Lorenzo, B A Yankner
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·M F PerutzJ T Finch
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K UédaT Saitoh
Oct 28, 1993·Nature·J C ChriviaR H Goodman
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·A LomakinD B Teplow
Nov 1, 1995·Trends in Biochemical Sciences·P J ThomasP L Pedersen
Oct 1, 1995·Current Opinion in Neurobiology·J F Gusella, M E MacDonald
Feb 1, 1996·Current Opinion in Structural Biology·J W Kelly

❮ Previous
Next ❯

Citations

Aug 30, 2011·The Analyst·Anthony J VelosoKagan Kerman
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Alina MaloyanJeffrey Robbins
Nov 6, 2007·Antioxidants & Redox Signaling·Martin Schröder, Kenji Kohno
Dec 21, 2006·Molecular and Cellular Biology·Elena KamyninaDanny Manor
Jul 26, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Patrick M McLendon, Jeffrey Robbins
Nov 3, 2007·Stroke; a Journal of Cerebral Circulation·Pengfei GeBingren Hu
Jul 21, 2010·Alzheimer's Research & Therapy·Kerensa BroersenJoost Schymkowitz
Feb 18, 2010·PloS One·Carlene S Starck, Andrew J Sutherland-Smith
Nov 5, 2010·PloS One·Anna Villar-PiquéSalvador Ventura
Jun 21, 2011·PloS One·Xiang Yu, Jie Zheng
Apr 1, 2014·Archives of Biochemistry and Biophysics·Nikolai N SluchankoNikolai B Gusev
Jun 6, 2014·BioMed Research International·Jana HroudováZdeněk Fišar
May 1, 2012·Applied Biochemistry and Biotechnology·Stefania PucciarelliGiovanni Filippo Palmieri
Aug 1, 2015·International Journal of Molecular Sciences·José Fernando Díaz-VillanuevaVictor García-González
Dec 17, 2008·The Journal of Cell Biology·Belinda S CowlingChristina A Mitchell
May 18, 2010·Neurobiology of Disease·Cindy VoisineRichard I Morimoto
Sep 9, 2009·Biophysical Chemistry·Damien Hall, Herman Edskes
Nov 2, 2007·Journal of Neurochemistry·Myung-Jeom RyuMyeong-Hee Yu
Feb 3, 2009·Biophysical Journal·Giovanni Bellesia, Joan-Emma Shea
Nov 4, 2009·Biophysical Journal·Innocent B Bekard, Dave E Dunstan
Apr 25, 2016·Progress in Neurobiology·Valerie JoersAnna R Carta
Jan 8, 2010·Current Opinion in Structural Biology·Tali GidalevitzRichard I Morimoto
Jun 4, 2014·The Journal of Physical Chemistry. B·Mingzhen ZhangJie Zheng
Sep 24, 2015·Scientific Reports·Vladimir V Vinogradov, David Avnir
Sep 28, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Dragana M BožinovskiSnežana D Zarić
Dec 16, 2017·Nature Reviews. Neurology·Juan Carlos PolancoJürgen Götz
Feb 28, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eszter Herczenik, Martijn F B G Gebbink
Oct 18, 2008·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·James M Gruschus
Jul 21, 2017·Neurochemical Research·Ivana PilchovaPeter Racay

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