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Protein Domain Hotspots Reveal Functional Mutations across Genes in Cancer

bioRxiv

Feb 26, 2015

Martin L MillerChris Sander

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Abstract

In cancer genomics, frequent recurrence of mutations in independent tumor samples is a strong indication of functional impact. However, rare functional mutations can escape detection by recurrence analysis for lack of statistical power. We address this problem by extending the notion of...read more

Mentioned in this Paper

FURIN gene
Homologous Gene
Detection
Mutation Abnormality
Oncogenes
ERBB4 Receptor Protein Tyrosine Kinase
Genetic Hotspot
Cancer Promoting Genes
Sequence Alignment
Recurrent Malignant Neoplasm
14
1
24
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  • Protein Domain Hotspots Reveal Functional Mutations across Genes in Cancer

    bioRxiv

    Feb 26, 2015

    Martin L MillerChris Sander

    PMID: 990015719

    DOI: 10.1101/015719

    Abstract

    In cancer genomics, frequent recurrence of mutations in independent tumor samples is a strong indication of functional impact. However, rare functional mutations can escape detection by recurrence analysis for lack of statistical power. We address this problem by extending the notion of...read more

    Mentioned in this Paper

    FURIN gene
    Homologous Gene
    Detection
    Mutation Abnormality
    Oncogenes
    14
    1
    24
    Paper Details
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      We're still populating references for this paper, please check back later.
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