PMID: 9187626Jun 1, 1997Paper

Protein-energy malnutrition delays small-intestinal recovery in neonatal pigs infected with rotavirus

The Journal of Nutrition
R T ZijlstraH R Gaskins

Abstract

Infectious diarrheal diseases and protein-energy malnutrition (PEM) are major causes of child morbidity and mortality worldwide. In the present study, PEM was superimposed on rotavirus infection in neonatal pigs to simulate chronic small intestinal stress in malnourished infants with viral gastroenteritis. Two-day-old cesarean-derived pigs (n = 39) were allotted to three treatment groups: 1) noninfected, full-fed; 2) infected, full-fed; and 3) infected, malnourished. Two days postinfection, severe diarrhea and weight loss (11%) were accompanied by reductions in villus height (60%) and lactase activity (78%) and increased crypt depth (32%) in infected full-fed compared with noninfected pigs (P < 0.05). Malnutrition blunted (P < 0.05) increases in crypt depth elicited by rotavirus. By 9 d postinfection, body weight was 59% less, villus height and lactase activity remained lower (50%), and crypt depth remained greater (62%) in infected full-fed compared with noninfected pigs (P < 0.05). However, diarrhea began to clear in infected full-fed, but not in infected malnourished pigs. Plasma insulin-like growth factor-I (IGF-I) was reduced 68% and crypt depth was reduced 19% in infected-malnourished compared with infected full-fed pigs ...Continue Reading

References

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Citations

Apr 16, 1999·The Journal of Nutrition·R T ZijlstraH R Gaskins
Jul 7, 2007·Journal of Animal Physiology and Animal Nutrition·J SehmM W Pfaffl
Aug 20, 2010·The American Journal of Clinical Nutrition·Shibani GhoshNevin S Scrimshaw
Apr 3, 2015·The Journal of Nutrition·Daniel J RaitenUNKNOWN INSPIRE Consultative Group
Jul 9, 2004·The Journal of Veterinary Medical Science·Apichai MekbungwanKoh-En Yamauchi
Nov 5, 2005·British Poultry Science·B Maneewan, K Yamauchi
Nov 24, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Ivona BaricevićJasminka Nedeljković
Dec 25, 2007·The Journal of Nutrition·Benjamin A CorlJ Marc Rhoads
Aug 7, 2007·Expert Review of Anti-infective Therapy·Robert F Ramig
Aug 15, 2000·Annual Review of Nutrition·R P Ferraris, H V Carey
Dec 2, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·J Marc RhoadsJack Odle
Feb 1, 2007·Animal : an International Journal of Animal Bioscience·F B SandbergI Kyriazakis
Jan 19, 2012·Nutrients·Daniel W BergnerMark S Kuhlenschmidt
Sep 16, 2004·Journal of Virology·Robert F Ramig
May 20, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·J Marc RhoadsLee M Graves
Jul 4, 2007·Journal of the American Veterinary Medical Association·Adam J Moeser, Anthony T Blikslager
Jun 23, 2018·BMC Gastroenterology·Anand KumarGireesh Rajashekara
Dec 4, 2020·Advances in Nutrition·Paul Kelly
Sep 13, 2017·Veterinary Immunology and Immunopathology·Gollahalli Eregowda ChethanUjjwal Kumar De
Aug 26, 2009·The Veterinary Journal·Steven McOrist, Kenneth H Mellits

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