Protein-Enriched Liquid Preloads Varying in Macronutrient Content Modulate Appetite and Appetite-Regulating Hormones in Healthy Adults

The Journal of Nutrition
Anestis Dougkas, Elin Östman

Abstract

Dietary protein is considered the most satiating macronutrient, yet there is little evidence on whether the effects observed are attributable to the protein or to the concomitant manipulation of carbohydrates and fat. The aim was to examine the effect of consumption of preloads varying in macronutrient content on appetite, energy intake, and biomarkers of satiety. Using a randomized, within-subjects, 2-level factorial design, 36 adults [mean ± SD age: 27 ± 5 y; body mass index (in kg/m(2)): 24.3 ± 1.6) received a breakfast consisting of 1 of 7 isovolumetric (670 mL) and isoenergetic (2100 kJ) liquid preloads matched for energy density and sensory properties but with different macronutrient composition (levels: 9%, 24%, or 40% of energy from protein combined with a carbohydrate-to-fat ratio of 0.4, 2, or 3.6, respectively). Appetite ratings and blood samples were collected and assessed at baseline and every 30 and 60 min, respectively, until a lunch test meal, which participants consumed ad libitum, was served 3.5 h after breakfast. Prospective consumption was 12% lower after intake of the high-protein (40%)/3.6 carbohydrate:fat preload than after intake of the low-protein (9%)/0.4 carbohydrate:fat preload (P = 0.02) solely beca...Continue Reading

Associated Clinical Trials

References

Jan 1, 1992·The American Journal of Clinical Nutrition·C de GraafP Jas
Jan 1, 1985·Journal of Psychosomatic Research·A J Stunkard, S Messick
Sep 25, 1998·Physiology & Behavior·S D PoppittR Buffenstein
Mar 7, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A FlintA Astrup
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Holly S CallahanDavid S Weigle
Sep 24, 2004·The British Journal of Nutrition·Martin R YeomansMicah Leshem
Nov 4, 2004·The Journal of Clinical Endocrinology and Metabolism·C W le RouxS R Bloom
Aug 24, 2006·Digestive Diseases and Sciences·H J BovenschenJ B M J Jansen
Jan 4, 2007·The Journal of Clinical Investigation·David E Cummings, Joost Overduin
Mar 9, 2007·The American Journal of Clinical Nutrition·Adam Drewnowski, France Bellisle
Jun 21, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D M MouraoR D Mattes
Oct 9, 2007·The American Journal of Clinical Nutrition·Rania Abou Samra, G Harvey Anderson
Jan 17, 2008·The Journal of Clinical Endocrinology and Metabolism·Karen E Foster-SchubertDavid E Cummings
May 13, 2008·The American Journal of Clinical Nutrition·Nikolaj T GregersenArne Astrup
May 13, 2008·The American Journal of Clinical Nutrition·Douglas Paddon-JonesMargriet Westerterp-Plantenga
Jan 15, 2009·European Journal of Nutrition·Margriet A B VeldhorstMargriet S Westerterp-Plantenga
Jan 30, 2009·The American Journal of Clinical Nutrition·Ananda Hochstenbach-WaelenKlaas R Westerterp
Feb 3, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Margriet A B VeldhorstMargriet S Westerterp-Plantenga
Feb 4, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J BlundellM Westerterp
May 4, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N DelzenneM Westerterp-Plantenga
Aug 28, 2010·International Journal of Peptides·Chrysi KoliakiNicholas Katsilambros
Sep 30, 2010·The British Journal of Nutrition·Nerys M AstburyIan A Macdonald
May 14, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J-A GilbertA Astrup
May 5, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ixchel M BrennanChristine Feinle-Bisset
Mar 8, 2013·The American Journal of Clinical Nutrition·Anita BelzaArne Astrup
May 15, 2013·Obesity·Agatha A van der KlaauwI Sadaf Farooqi
Jul 3, 2013·Nutrition Reviews·Eva Almiron-RoigAdam Drewnowski
Jul 5, 2013·Nutrition & Metabolism·Robin A McGregor, Sally D Poppitt
Aug 8, 2013·The British Journal of Nutrition·Tomasz WikarekMagdalena Olszanecka-Glinianowicz

❮ Previous
Next ❯

Citations

Apr 4, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T PribicF Azpiroz
Mar 6, 2018·Obesity·Emma J StinsonSusanne B Votruba
Aug 11, 2018·Bioscience, Biotechnology, and Biochemistry·Wenya ChenHiroshi Hara
May 10, 2017·Frontiers in Endocrinology·Juliette CaronBenoit Cudennec
Mar 30, 2021·Critical Reviews in Food Science and Nutrition·Fatma BoukidMassimo Castellari
Jul 3, 2021·International Journal of Molecular Sciences·Tohru HiraHiroshi Hara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.