Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection

Molecular Oncology
Matthias KolbergR A Lothe

Abstract

No consensus treatment regime exists beyond surgery for malignant peripheral nerve sheath tumours (MPNST), and the purpose of the present study was to find new approaches to stratify patients with good and poor prognosis and to better guide therapeutic intervention for this aggressive soft tissue cancer. From a total of 67 MPNSTs from Scandinavian patients with and without neurofibromatosis type 1, 30 MPNSTs were investigated by genome-wide RNA expression profiling and 63 MPNSTs by immunohistochemical (IHC) analysis, and selected genes were submitted to analyses of disease-specific survival. The potential drug target genes survivin (BIRC5), thymidine kinase 1 (TK1), and topoisomerase 2-alpha (TOP2A), all encoded on chromosome arm 17q, were up-regulated in MPNST as compared to benign neurofibromas. Each of them was found to be independent prognostic markers on the gene expression level, as well as on the protein level. A prognostic profile was identified by combining the nuclear expression scores of the three proteins. For patients with completely resected tumours only 15% in the high risk group were alive after two years, as compared to 78% in the low risk group. In conclusion, we found a novel protein expression profile which ...Continue Reading

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A G MenonF P Li
Jan 1, 1995·Journal of Neuropathology and Experimental Neurology·R A LotheJ M Nesland
Dec 11, 1999·Science·K CichowskiT Jacks
Dec 11, 1999·Science·K S VogelL F Parada
Jun 19, 2002·Acta Neuropathologica·Tsutomu SasakiGregory A Helm
Aug 3, 2002·Nature Reviews. Cancer·Yuan Zhu, Luis F Parada
Dec 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rolf I SkotheimRagnhild A Lothe
Sep 28, 2004·Brain Pathology·Nikola HoltkampAndreas von Deimling
Jan 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pascale LévyIvan Bièche
Jun 5, 2008·Molecular Cancer·Stine H KresseLeonardo A Meza-Zepeda
Jul 25, 2008·Neuro-oncology·Nikola HoltkampAndreas von Deimling
Sep 5, 2008·Sarcoma·Séverine Tabone-EglingerJean-François Emile
Jan 15, 2009·The Journal of Pathology·Irene BottilloBruno Dallapiccola
Mar 31, 2009·Journal of Neuro-oncology·Daniel KeizmanOfer Merimsky
Jun 30, 2009·Cancer Treatment Reviews·Bríd M RyanMichael J Duffy
Oct 20, 2009·Expert Reviews in Molecular Medicine·Daniela KatzDina Lev
Dec 17, 2009·Journal of Neuropathology and Experimental Neurology·Robert M VerdijkJohan M Kros
Feb 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Helge R BrekkeRagnhild A Lothe
Feb 18, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jinsheng YuArie Perry
Nov 2, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jilong YangWei Zhang
Nov 10, 2011·Cancer Letters·Stefan AufderklammChristian Schwentner
Dec 14, 2011·Acta Neuropathologica·Steven L Carroll
Mar 13, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Markus P GhadimiDina Lev
Jul 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ami V PatelNancy Ratner
Aug 25, 2012·Current Opinion in Hematology·Giacomo OliveiraChiara Bonini
Nov 20, 2012·Human Genomics·Ashni SedaniMeena Upadhyaya

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Citations

Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jianjun WangSven Skog
May 30, 2019·Scientific Reports·Yuki KataokaHiroyuki Kitao
Mar 19, 2019·Cancer Biomarkers : Section a of Disease Markers·Malgorzata A KrawczykEwa Bien
Jan 16, 2021·Journal of the Peripheral Nervous System : JPNS·M Laura FeltriYannick Poitelon
Apr 20, 2021·Biochemical and Biophysical Research Communications·Rongsheng HuangAtsunori Kamiya

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Datasets Mentioned

BETA
GSE66743
GPL2986

Methods Mentioned

BETA
genotyping
surgical remission
PCR

Clinical Trials Mentioned

NCT00304083

Software Mentioned

Partek Genomics Suite
SPSS
DAVID
Significance Analysis of Microarrays Excel Add ‐ in
SAM
ABarray

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