Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC).

Journal of Cancer Research and Clinical Oncology
Jenny HötzelMichael Tachezy

Abstract

The cell adhesion molecule close homologue of L1 (CHL1) is a potential tumour suppressor and was recently detected in non-small cell lung cancer (NSCLC) specimens. The expression pattern, prognostic, and functional role of CHL1 in NSCLCs is unknown. We evaluated the protein expression of CHL1 by immunohistochemistry in 2161 NSCLC patients based on a tissue microarray. The results were correlated with clinical, histopathological, and patient survival data (Chi square test, t test, and log-rank test, respectively). A multivariate analysis (Cox regression) was performed to validate its impact on patients' survival. CHL1 was expressed in NSCLC patients and was significantly overexpressed in lung adenocarcinomas and squamous cell carcinomas compared to neuroendocrine and large cell carcinomas of the lung (p < 0.001). CHL1 expression was associated with the T stage in adenocarcinomas (p = 0.011) and with metastatic lymph node status and UICC stage in squamous cell carcinomas (p = 0.034 and p = 0.035, respectively). Increased CHL1 expression was associated with improved survival in univariate (p = 0.031) and multivariate analyses (odds ratio 0.797, 95% confidence interval 0.677-0.939, p = 0.007). The prognostic significance of CHL1 ma...Continue Reading

References

Jan 16, 2009·Cancer Letters·Shani RavehAvri Ben-Ze'ev
Jun 2, 2009·Cell Adhesion & Migration·Priscila F Siesser, Patricia F Maness
Dec 18, 2009·Advances in Experimental Medicine and Biology·Silvia Zecchini, Ugo Cavallaro
Aug 7, 2010·Methods in Molecular Biology·Ronald SimonGuido Sauter
Mar 17, 2011·PloS One·Vera N SenchenkoMichael I Lerman
Aug 6, 2011·The Journal of Surgical Research·Michael TachezyMaximilian Bockhorn
Aug 3, 2013·Biochemical and Biophysical Research Communications·Li-Hong HeZhong-Sheng Tong
Aug 15, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ReckUNKNOWN ESMO Guidelines Working Group
Dec 17, 2015·Methods in Molecular Biology·Ana-Maria DancauGuido Sauter
Feb 9, 2017·Oncotarget·Esperanza Martín-SánchezDavid Guerrero-Setas
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Meng Shen, Xiubao Ren
Nov 16, 2017·Cancers·Tatiana N ZamayAnna S Kichkailo
Mar 24, 2018·Oncotarget·Wen TianBaosen Zhou
May 19, 2018·Biochemical and Biophysical Research Communications·Norihiro KotaniTakayuki Murakoshi
Jun 15, 2018·Oncotarget·Marzia OgnibeneAnnalisa Pezzolo

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