Protein expression of HER2, 3, 4 in gastric cancer: correlation with clinical features and survival

Journal of Clinical Pathology
Xiao Xiao HeLing Xue

Abstract

Despite significant improvements in targeted therapies for patients with advanced gastric cancer (GC), the prognosis of those patients remains poor. This study explores the expression and clinicopathological significance of human epidermal growth factor receptor 2, 3 and 4 (HER2, HER3, HER4) in GC, in order to find more prognostic biomarkers of GC and putative targets of therapy. Immunohistochemistry was performed for HER2, HER3 and HER4 in 498 patients with GC using tissue microarray. Correlations between the receptor expression and clinicopathological features, as well as prognosis of the patients were statistically analysed. The high expression rates of HER2, HER3 and HER4 proteins in the patients were 8.6% (43/498), 20.7% (103/498) and 13.3% (66/498), respectively. High expression of HER2 and HER3 was correlated with proximal GC of the cardia (p<0.05). High expression of HER3 was associated with the tumour depth, tumour node metastasis (TNM) stage and lymph node metastasis (p<0.05). High expression of HER4 was associated with TNM stage (p<0.05) only. According to a regression model, high expression of HER3 was significantly associated with patients' poor survival (p=0.004). High expression rates of HER2, HER3 and HER4 were ...Continue Reading

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Citations

Dec 23, 2017·Cell Biology International·Ming BaiYunpeng Liu
Feb 7, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Jong Won LeeYeul Hong Kim
Oct 31, 2015·Oncotarget·Yadong WangGuangcai Duan
Jun 3, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Sumi YunHye Seung Lee
Jan 21, 2017·TheScientificWorldJournal·Roberto de Moraes Cordts FilhoCarlos Alberto Malheiros
Dec 19, 2019·Frontiers in Oncology·Chiara ArientiAnna Tesei
Aug 6, 2020·OncoTargets and Therapy·Xiang GaoYuxing Xu
Dec 14, 2018·International Archives of Allergy and Immunology·Sergey Vitalievich SennikovJulia A Lopatnikova

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