PMID: 9434909Jan 22, 1998Paper

Protein farnesyltransferase

Current Opinion in Structural Biology
H W Park, Lorena S Beese

Abstract

In the past year, the crystal structure of alpha beta heterodimeric protein farnesyltransferase from rat was reported to a resolution of 2.25 A. Farnesyltransferase catalyzes the essential post-translational lipidation of Ras and several other cellular signal transduction proteins. The structure provides a foundation for understanding the specificity and mechanism of protein prenylation and may aid in the design of new anticancer therapeutics.

References

Jan 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Sinensky, R J Lutz
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W J ChenM S Brown
Dec 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W A Maltese
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L E GoodmanF Tamanoi
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J H JacksonC J Der
Apr 1, 1990·Trends in Biochemical Sciences·J A GlomsetC C Farnsworth
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P J CaseyJ E Buss
Nov 5, 1988·Journal of Molecular Biology·J JaninC Chothia
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·J M Dolence, C D Poulter
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·L Song, C D Poulter
May 13, 1994·Journal of Molecular Biology·A E AleshinR B Honzatko
Nov 30, 1993·Biochemistry·S J StradleyL M Gierasch
Mar 8, 1996·The Journal of Biological Chemistry·P J Casey, M C Seabra
Jan 1, 1996·Annual Review of Biochemistry·F L Zhang, P J Casey
Jan 1, 1996·Breast Cancer Research and Treatment·J B GibbsA Oliff
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·L C TarshisC D Poulter
Apr 11, 1997·The Journal of Biological Chemistry·W R TschantzP J Casey
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·J B Gibbs, A Oliff
Jan 1, 1997·Biopolymers·Y QianA D Hamilton
Oct 27, 1997·The Journal of Biological Chemistry·A M KralC A Omer

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Citations

Jan 4, 2003·Archives of Pharmacal Research·Kwang-Nym Cho, Kee-In Lee
Oct 15, 2013·International Journal of Medical Microbiology : IJMM·Friedrich GötzMartin Schlag
Sep 7, 2005·Analytical Biochemistry·June E PaisCarol A Fierke
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A HuwilerJ Pfeilschifter
Jun 27, 2009·Journal of Enzyme Inhibition and Medicinal Chemistry·Laëtitia CoudrayJoëlle Dubois
Apr 18, 2001·The Journal of Biological Chemistry·M M WrightC R McMaster
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kui LiuEdward K Wakeland
Sep 24, 2009·Journal of Medicinal Chemistry·Sébastien LethuJoëlle Dubois
Jun 20, 2014·Bioconjugate Chemistry·Jonathan K DozierMark D Distefano

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