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Protein folding and binding can emerge as evolutionary spandrels through structural coupling

bioRxiv

Aug 20, 2014

Michael Manhart, Alexandre V. Morozov

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Abstract

Binding interactions between proteins and other molecules mediate numerous cellular processes, including metabolism, signaling, and regulation of gene expression. These interactions evolve in response to changes in the protein's chemical or physical environment (such as the addition of ...read more

Mentioned in this Paper

Protein Folding
Gene Expression
Biophysics
High Throughput Screening
Study
Protein Binding
Cellular Process
Mutation Abnormality
Adaptation
Protein Misfolding Disorders
6
43
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  • Protein folding and binding can emerge as evolutionary spandrels through structural coupling

    bioRxiv

    Aug 20, 2014

    Michael Manhart, Alexandre V. Morozov

    PMID: 990008250

    DOI: 10.1101/008250

    Abstract

    Binding interactions between proteins and other molecules mediate numerous cellular processes, including metabolism, signaling, and regulation of gene expression. These interactions evolve in response to changes in the protein's chemical or physical environment (such as the addition of ...read more

    Mentioned in this Paper

    Protein Folding
    Gene Expression
    Biophysics
    High Throughput Screening
    Study
    6
    43

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