Protein folding by 'levels of separation': a hypothesis

FEBS Letters
Lesley H Greene, Terri M Grant

Abstract

The protein folding process has been studied both computationally and experimentally for over 30 years. To date there is no detailed mechanism to explain the formation of long-range interactions between the transition and native states. Long-range interactions are the principle determinants of the tertiary structure. We present a theoretical model which proposes a mechanism for the acquisition of these interactions as they form in a modified version of 'degrees of separation', that we term 'levels of separation'. It is based on the integration of network science and biochemistry.

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Citations

Jul 20, 2012·Briefings in Functional Genomics·Ali Rana Atilgan, Canan Atilgan
Oct 9, 2012·Briefings in Functional Genomics·Lesley H Greene
May 4, 2017·Substance Use & Misuse·Nathan J Doogan, Keith L Warren
Jul 19, 2019·The Protein Journal·Zeinab HaratipourLesley H Greene
May 18, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Vladimir P Zhdanov, Fredrik Höök

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