PMID: 7035830Jan 1, 1981Paper

Protein H encoded by plasmid Clo DF13 involved in lysis of the bacterial host. II. Functions and regulation of synthesis of the gene H product

Molecular & General Genetics : MGG
M J HakkaartH J Nijkamp

Abstract

We studied the expression of gene H, located between 9.3% and 11% on the CLo DF13 genome, as well as the functions of the gene product. We found that treatment of bacterial cells with mitomycin-C results in the induced synthesis of three Clo DF13 specified proteins namely cloacin DF13, immunity protein and protein H. Evidence was obtained that the genes encoding these proteins form one, mitomycin-C induceable, operon; the promoter at 32% in front of the cloacin gene is essential for the induced expression. Furthermore we could demontrate that protein H is involved in the lethal effect of mitomycin-C treatment of bacteriocinogenic cells. The data in this paper show that a high concentration of protein H in cells, due either to an induced expression of gene H (mitomycin-C induction) or to a gene dosage effect (Clo DF13 copl Ts copy control mutant), results in the lysis of bacterial cells. The implication of these data are discussed.

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Citations

Apr 16, 1984·European Journal of Biochemistry·M Yamada, A Nakazawa
Mar 20, 1985·Journal of Molecular Biology·H Masaki, T Ohta
Jan 1, 1984·Molecular & General Genetics : MGG·T OlschlägerV Braun
Jan 1, 1987·Molecular & General Genetics : MGG·J LuirinkB Oudega
Jun 1, 1982·Journal of Bacteriology·B OudegaF K de Graaf
Mar 1, 1983·Journal of Bacteriology·J F SabikS E Luria
Feb 1, 1984·Journal of Bacteriology·K S Jakes, N D Zinder
Nov 1, 1986·Journal of Bacteriology·M AltieriS E Luria
Mar 10, 2007·Microbiology and Molecular Biology Reviews : MMBR·Eric CascalesDanièle Cavard
Apr 1, 1986·Journal of Bacteriology·J FreyM Belet

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