Protein homeostasis and aging: role of ubiquitin protein ligases

Neurochemistry International
Nihar Ranjan Jana

Abstract

Protein homeostasis is fundamental in normal cellular function and cell survival. The ubiquitin-proteasome system (UPS) plays a central role in maintaining the protein homeostasis network through selective elimination of misfolded and damaged proteins. Impaired function of UPS is implicated in normal aging process and also in several age-related neurodegenerative disorders that are characterized by increased accumulation oxidatively modified proteins and protein aggregates. Growing literature also indicate the potential role of various ubiquitin protein ligases in the regulation of aging process by enhancing the degradation of either central lifespan regulators or abnormally folded and damaged proteins. This review mainly focuses on our current understanding of the importance of UPS function in the regulation of normal aging process.

References

Sep 1, 1995·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·H OhtsukaS Goto
Mar 22, 1996·Cell·M Hochstrasser
Jan 1, 1997·Nature Genetics·T KishinoJ Wagstaff
Oct 17, 1998·Nature·E LeroyM H Polymeropoulos
May 25, 1999·Cell·J D Laney, M Hochstrasser
Jun 25, 1999·Cell Death and Differentiation·R Z Orlowski
Nov 7, 1999·The Journal of Membrane Biology·R Z SabirovY Okada
Mar 9, 2000·Mechanisms of Ageing and Development·J N KellerW R Markesbery
Apr 20, 2001·Mechanisms of Ageing and Development·M GaczynskaW F Ward
Mar 28, 2002·Physiological Reviews·Michael H Glickman, Aaron Ciechanover
Jun 1, 2002·Ageing Research Reviews·Jeffrey N KellerQunxing Ding
Jul 13, 2002·Trends in Biochemical Sciences·Douglas M CyrCam Patterson
Aug 30, 2002·The International Journal of Biochemistry & Cell Biology·Géraldine CarrardBertrand Friguet
Jan 9, 2003·Trends in Biochemical Sciences·Rasmus Hartmann-PetersenColin Gordon
Aug 29, 2003·Science of Aging Knowledge Environment : SAGE KE·Douglas A GrayJohn Woulfe
Sep 6, 2003·Nature Genetics·Elayne M ChanStephen W Scherer
Oct 3, 2003·Ageing Research Reviews·Michele MishtoClaudio Franceschi
Jan 1, 2004·The Journal of Biological Chemistry·Nihar Ranjan JanaNobuyuki Nukina
Aug 25, 2004·The International Journal of Biochemistry & Cell Biology·Jeffrey N KellerQunxing Ding
Jan 25, 2005·The Journal of Biological Chemistry·Nihar Ranjan JanaNobuyuki Nukina
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Aaron Ciechanover
Jun 21, 2005·Neurobiology of Aging·M Paz GavilánDiego Ruano
Jul 7, 2005·Genes & Development·Benjamin HamiltonSiu Sylvia Lee
Oct 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Victor M MillerHenry L Paulson
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Jordi BovéSerge Przedborski
Feb 14, 2006·Biochemical and Biophysical Research Communications·Anand GoswamiNihar Ranjan Jana
Feb 21, 2006·Antioxidants & Redox Signaling·Qunxing DingJeffrey N Keller
Feb 21, 2006·Antioxidants & Redox Signaling·Luc Farout, Bertrand Friguet
May 24, 2006·Neurology·Kevin St P McNaughtC Warren Olanow
Jun 7, 2006·Annual Review of Cell and Developmental Biology·Oliver KerscherMark Hochstrasser
Nov 23, 2006·Journal of Receptor and Signal Transduction Research·Davide Genini, Carlo V Catapano
Mar 21, 2007·Nature Cell Biology·Philipp Christoph JanieschThorsten Hoppe
Mar 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Arjumand GhaziCynthia Kenyon
Apr 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vita A VernaceMaria E Figueiredo-Pereira
May 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hiroaki AdachiGen Sobue

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Citations

Mar 16, 2013·EMBO Molecular Medicine·Huize PanJuan Carlos Izpisua Belmonte
Jul 6, 2014·Neurochemistry International·Artur Dawid SurowkaMagdalena Szczerbowska-Boruchowska
Oct 11, 2014·BioMed Research International·Loren PickartAnna Margolina
Jan 7, 2015·Molecular Neurobiology·Yanuar Alan Sulistio, Klaus Heese
Nov 19, 2015·Journal of Cellular Physiology·Jingjing FanNing Chen
Nov 12, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Yanuar Alan Sulistio, Klaus Heese
Jul 21, 2015·Biochimica Et Biophysica Acta·Autumn TocchiPeter S Rabinovitch
Jul 22, 2014·Neuropathology and Applied Neurobiology·Zoya MarinovaEdna Grünblatt
Feb 8, 2014·Ageing Research Reviews·Amy ReeveDoug Turnbull
Sep 4, 2012·Ageing Research Reviews·Arnold De LoofLiliane Schoofs
Jan 7, 2014·Journal of Neural Transmission·Thomas FreretAurel Popa-Wagner
Feb 24, 2015·Ageing Research Reviews·Ellen K QuarlesPeter S Rabinovitch
Apr 1, 2014·Free Radical Biology & Medicine·Niki ChondrogianniEfstathios S Gonos
Feb 18, 2018·Proteomics·Nathan BasistyBirgit Schilling
Sep 29, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Nathan B BasistyPeter S Rabinovitch
May 27, 2016·American Journal of Physiology. Cell Physiology·Martina P Liebl, Thorsten Hoppe
Dec 28, 2019·Cancers·Nikolaos AntoniouVassilis G Gorgoulis
Dec 4, 2019·Frontiers in Aging Neuroscience·Domenico SergiMaria-Grazia Martinoli
Aug 16, 2018·Pflügers Archiv : European journal of physiology·Larissa M DorschBianca J J M Brundel
Dec 1, 2019·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Silpa NarayananZhe-Sheng Chen
Mar 15, 2013·Journal of Medicinal Chemistry·Bruno BulicEckhard Mandelkow
Nov 7, 2021·The Journal of Pharmacology and Experimental Therapeutics·Tianxiao WangQunyi Li

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