PMID: 6537266Jan 1, 1984Paper

Protein interaction: concepts from thermodynamic measurements

Biomaterials, Medical Devices, and Artificial Organs
M Jamaluddin, L Kalliyanakrishnan

Abstract

Proteins are biological molecules par excellence. They have evolved as elements of structure, catalysis and control. The conflict between the requirement of structural stability and the requirement of functional specificity and efficiency, under varying environmental conditions in which they are often called upon to function, has been evolutionarily solved by a process of thermodynamic compensation. In the simplest form of thermodynamic compensation the Gibb's free energy change (delta G) of a process occurring under different environmental conditions is kept constant (linear compensation) or allowed to vary slightly (non linear compensation) by compensating a large change in enthalpy (delta H) by an equally (or nearly 80) large change in entropy, delta S. In processes like protein adsorption to surfaces the number of various types of interactions involved is so large that compensatory or augmenting changes in the same type of thermodynamic parameter may occur and complicate the picture. Published data do, however, suggested the occurrence of thermodynamic compensation in protein adsorption. It is pointed out that the simultaneous measurement of two thermodynamic parameters, namely, enthalpy change (delta H), and heat capacity ...Continue Reading

References

Jun 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J M Sturtevant
Aug 1, 1977·Quarterly Reviews of Biophysics·G Némethy, H A Scheraga
Aug 28, 1975·Nature·C Chothia, J Janin
May 20, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M F Perutz
Jan 1, 1974·Advances in Protein Chemistry·I D Kuntz, W Kauzmann
Nov 21, 1972·European Journal of Biochemistry·C Bjurulf, I Wadsö
Nov 5, 1965·Journal of the American Chemical Society·G G Hammes, P R Schimmel
Sep 26, 1966·Archives of Biochemistry and Biophysics·I M Klotz
Dec 24, 1981·Nature·H Möhler, J G Richards
Sep 15, 1958·Canadian Medical Association Journal·W A DUTTON
May 1, 1965·Journal of Molecular Biology·J MONODJ P CHANGEUX
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R Smith, C Tanford

❮ Previous
Next ❯

Citations

Apr 1, 1993·Journal of Biomaterials Applications·P R Hari, C P Sharma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.