Protein interactors of acyl-CoA-binding protein ACBP2 mediate cadmium tolerance in Arabidopsis.

Plant Signaling & Behavior
Wei GaoMee-Len Chye

Abstract

In our recent paper in the Plant Journal, we reported that Arabidopsis thaliana lysophospholipase 2 (lysoPL2) binds acyl-CoA-binding protein 2 (ACBP2) to mediate cadmium [Cd(II)] tolerance in transgenic Arabidopsis. ACBP2 contains ankyrin repeats that have been previously shown to mediate protein-protein interactions with an ethylene-responsive element binding protein (AtEBP) and a farnesylated protein 6 (AtFP6). Transgenic Arabidopsis ACBP2-overexpressors, lysoPL2-overexpressors and AtFP6-overexpressors all display enhanced Cd(II) tolerance, in comparison to wild type, suggesting that ACBP2 and its protein partners work together to mediate Cd(II) tolerance. Given that recombinant ACBP2 and AtFP6 can independently bind Cd(II) in vitro, they may be able to participate in Cd(II) translocation. The binding of recombinant ACBP2 to [(14)C]linoleoyl-CoA and [(14)C]linolenoyl-CoA implies its role in phospholipid repair. In conclusion, ACBP2 can mediate tolerance to Cd(II)-induced oxidative stress by interacting with two protein partners, AtFP6 and lysoPL2. Observations that ACBP2 also binds lysophosphatidylcholine (lysoPC) in vitro and that recombinant lysoPL2 degrades lysoPC, further confirm an interactive role for ACBP2 and lysoPL2 ...Continue Reading

References

Dec 1, 1985·Archives of Biochemistry and Biophysics·Y Fujikura, D Baisted
Feb 1, 1995·Free Radical Biology & Medicine·S J Stohs, D Bagchi
Mar 5, 1999·Biochimica Et Biophysica Acta·T ToyodaS Yamashita
Jul 9, 1999·Biochimica Et Biophysica Acta·A Wang, E A Dennis
Jul 13, 2000·Plant Physiology·C S Cobbett
Aug 15, 2000·Plant Science : an International Journal of Experimental Plant Biology· Madhava Rao KV, T V Sresty
May 9, 2002·Journal of Experimental Botany·Andres Schützendübel, Andrea Polle
Aug 17, 2002·Molecular Plant-microbe Interactions : MPMI·Marta de Torres ZabelaMurray Grant
Mar 15, 2006·Plant Physiology and Biochemistry : PPB·Consuelo GuerreroAntonio Heredia
Jul 28, 2006·Molecular Biology of the Cell·Morten K LarsenJens Knudsen
Mar 16, 2007·The Plant Journal : for Cell and Molecular Biology·Do-Young KimYoungsook Lee
Jan 10, 2008·The Plant Journal : for Cell and Molecular Biology·Shi XiaoMee-Len Chye
Nov 5, 2008·The Plant Journal : for Cell and Molecular Biology·Robert BlanvillainDavid W Ow
Jan 6, 2009·Plant Physiology and Biochemistry : PPB·Shi Xiao, Mee-Len Chye

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.