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Protein interferon-stimulated gene 15 conjugation delays but does not overcome coronavirus proliferation in a model of fulminant hepatitis

Journal of Virology

Mar 22, 2014

Xuezhong MaIan D McGilvray

Abstract

Coronaviruses express a deubiquitinating protein, the papain-like protease-2 (PLP2), that removes both ubiquitin and the ubiquitin-like interferon (IFN)-stimulated gene 15 (ISG15) protein from target proteins. ISG15 has antiviral activity against a number of viruses; therefore, we exami...read more

Mentioned in this Paper

Macrophages, Peritoneal
Immune Response
Biochemical Pathway
Conjugation
Histology Procedure
Systemic Inflammatory Response Syndrome
G1p2 protein, mouse
Ubiquitin
PLP2 gene
Peptide Hydrolases
17
1
Paper Details
References
  • References54
  • Citations7
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  • References54
  • Citations7

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Protein interferon-stimulated gene 15 conjugation delays but does not overcome coronavirus proliferation in a model of fulminant hepatitis

Journal of Virology

Mar 22, 2014

Xuezhong MaIan D McGilvray

PMID: 24648452

DOI: 10.1128/jvi.03801-13

Abstract

Coronaviruses express a deubiquitinating protein, the papain-like protease-2 (PLP2), that removes both ubiquitin and the ubiquitin-like interferon (IFN)-stimulated gene 15 (ISG15) protein from target proteins. ISG15 has antiviral activity against a number of viruses; therefore, we exami...read more

Mentioned in this Paper

Macrophages, Peritoneal
Immune Response
Biochemical Pathway
Conjugation
Histology Procedure
Systemic Inflammatory Response Syndrome
G1p2 protein, mouse
Ubiquitin
PLP2 gene
Peptide Hydrolases
17
1

Similar Papers Found In These Feeds

Human Cell Atlas Consortium

The aim of the Human Cell Atlas is to build reference maps of all human cells in order to enhance our understanding of health and disease. Follow the latest research from the Human Cell Atlas Consortium here.

Oxygenation & Hydroxylation

Oxygenation is a chemical production that introduces oxygen atom into an organic compound. Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Cytochrome P450 (CYP) enzymes are expressed mainly in the liver and are active in mono-oxygenation and hydroxylation of various xenobiotics, including drugs and alcohols, as well as that of endogenous compounds such as steroids, bile acids, prostaglandins, leukotrienes and biogenic amines. Here is the latest research.

Related Papers

The International Journal of Biochemistry & Cell Biology

The ISG15/USP18 ubiquitin-like pathway (ISGylation system) in hepatitis C virus infection and resistance to interferon therapy

The International Journal of Biochemistry & Cell BiologyJune 28, 2011
Limin ChenIan D McGilvray
Paper Details
References
  • References54
  • Citations7
12345...
  • References54
  • Citations7
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