PMID: 9184643Jun 1, 1997Paper

Protein kinase A-dependent IL-6 production induced by calcitonin in human glioblastoma A172 cells

Journal of Neuroimmunology
Y KiriyamaY Nomura

Abstract

In human glioblastoma A172 cells, interleukin-6 (IL-6) production was induced by interleukin-1 beta (IL-1 beta) and dibutyryl cyclic AMP. These cells have been shown to induce IL-6 production via a cAMP-protein kinase A system. Since calcitonin (CT) and calcitonin gene-related peptide (CGRP) are known to increase cAMP accumulation in murine and rat astrocytes, we examined whether these neuropeptides induced IL-6 production in A172 cells. Human CT and human CGRP increased IL-6 production and cAMP accumulation in a dose-dependent manner. A specific protein kinase A inhibitor, H-89, inhibited both CT- and CGRP-induced IL-6 production. CT and CGRP have been shown to cross-react with each other. To exclude the possibility of this cross-reactivity, we studied the additive effects of CT and CGRP and the inhibitory effects of specific inhibitors. When 100 nM CT was added, cAMP accumulation stimulated by 10 nM CGRP (the maximal dose) was increased. CGRP (8-37), a specific CGRP receptor inhibitor, inhibited cAMP accumulation and IL-6 production induced by CGRP, but did not inhibit these effects when they were induced by CT. Salmon CT (8-32), a specific inhibitor of the CT receptor, inhibited cAMP accumulation induced by CT, but did not i...Continue Reading

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Citations

Mar 1, 2000·Journal of Neuroimmunology·N J Van Wagoner, E N Benveniste
Jan 5, 2002·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Y Nomura
Sep 25, 2002·Physiological Reviews·Linda R Watkins, Steven F Maier

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