Abstract
Protein kinase B alpha (PKB alpha/Akt1) is implicated in the regulation of metabolism, transcription, cell survival, angiogenesis, cell migration, growth, and tumorigenesis. Previously, it was reported that PKB alpha-deficient mice are small with increased neonatal mortality (Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F., and Birnbaum, M. J. (2001) J. Biol. Chem. 276, 38349-38352 and Chen, W. S., Xu, P. Z., Gottlob, K., Chen, M. L., Sokol, K., Shiyanova, T., Roninson, I., Wenig, W., Suzuki, R., Tobe, K., Kadowaki, T., and Hay, N. (2001) Genes Dev. 15, 2203-2208). Here we show that PKB alpha is widely expressed in placenta including all types of trophoblast and vascular endothelial cells. Pkb alpha-/- placentae display significant hypotrophy, with marked reduction of the decidual basalis and nearly complete loss of glycogen-containing cells in the spongiotrophoblast, and exhibit decreased vascularization. Pkb alpha-/- placentae also show significant reduction of phosphorylation of PKB and endothelial nitric-oxide synthase. These defects may cause placental insufficiency, fetal growth impairment, and neonatal mortality. These data represent the first evidence for the role of PKB alpha and endothelial nitricoxide synthase in regu...Continue Reading
References
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P F JonesB A Hemmings
May 1, 1996·Endocrinology·M F LopezL Villa-Komaroff
Jun 10, 1998·Oncogene·D A AltomareJ R Testa
Aug 29, 1998·Molecular and Cellular Endocrinology·M van KleffensS L Drop
Feb 13, 1999·Cell·I Conlon, M Raff
Jun 22, 1999·Nature·D FultonW C Sessa
Jun 22, 1999·Nature·S DimmelerA M Zeiher
Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Dec 10, 1999·Nature Cell Biology·J VerduM J Birnbaum
May 10, 2000·Current Biology : CB·M R WilliamsD R Alessi
Aug 16, 2000·Cell·J N Ihle
Aug 23, 2000·The Journal of Clinical Investigation·Z LuoK Walsh
Sep 6, 2000·Nature Medicine·Y KureishiK Walsh
Feb 13, 2001·Biology of Reproduction·L A HeflerA R Gregg
Apr 5, 2001·Trends in Molecular Medicine·S Okada, J J Kopchick
May 18, 2001·Nature·P Blume-Jensen, T Hunter
Jun 2, 2001·Science·H ChoM J Birnbaum
Jul 4, 2001·Nature Reviews. Genetics·J Rossant, J C Cross
Jul 18, 2001·Circulation·H DuplainU Scherrer
Sep 5, 2001·Current Opinion in Genetics & Development·J Rathjen, P D Rathjen
Sep 5, 2001·The Journal of Biological Chemistry·H ChoM J Birnbaum
Sep 7, 2001·Genes & Development·W S ChenN Hay
Oct 9, 2001·Nature Medicine·R L TuttleM J Birnbaum
Oct 31, 2001·Molecular Cell·M LeitgesJ Moscat
Jan 5, 2002·Current Opinion in Pharmacology·V K Han, A M Carter
Mar 2, 2002·Science·Hugo StockerErnst Hafen
Mar 23, 2002·Molecular and Cellular Biology·Tetsuo ShioiSeigo Izumo
Apr 12, 2002·The Journal of Biological Chemistry·Takashi MatsuiAnthony Rosenzweig
Apr 30, 2002·Placenta·T R H RegnaultR V Anthony
Apr 30, 2002·Placenta·Giorgio PardiIrene Cetin
May 2, 2002·Nature Medicine·Ali Hafezi-MoghadamJames K Liao
May 4, 2002·Molecular and Cellular Endocrinology·J C CrossS L Adamson
May 4, 2002·Circulation Research·Ramona S ScotlandWilliam C Sessa
Jun 28, 2002·Cancer Cell·Sandra OrsulicHarold E Varmus
Jun 29, 2002·Molecular Endocrinology·Takayuki KameiMichael J Soares
Aug 13, 2002·Nature Cell Biology·Ken InokiKun-Liang Guan
Aug 13, 2002·Nature Cell Biology·Christopher J PotterTian Xu
Aug 13, 2002·Nature Cell Biology·Xinsheng GaoDuojia Pan
Oct 12, 2002·Developmental Biology·S Lee AdamsonJames C Cross
Citations
Jun 26, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gesa KreySandra M Blois
May 26, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jennifer DackorDavid W Threadgill
Sep 17, 2010·Functional & Integrative Genomics·Heather A AdamsSandra L Rodriguez-Zas
Apr 23, 2011·Journal of Molecular Histology·Asli OzmenEmin Turkay Korgun
Mar 17, 2004·Biochimica Et Biophysica Acta·Masahito HanadaBrian A Hemmings
Apr 20, 2005·Placenta·P M CoanA C Ferguson-Smith
Jan 12, 2012·Expert Reviews in Molecular Medicine·Simon M SchultzeOliver Tschopp
Jun 22, 2013·Cell Death and Differentiation·B D GreenP G Ekert
Feb 12, 2008·Nature Cell Biology·Tomoya KitamuraMasahide Takahashi
May 19, 2011·Nature Communications·Noboru AshidaAnthony Rosenzweig
Dec 13, 2005·Nature Reviews. Drug Discovery·Bryan T HennessyGordon B Mills
Nov 29, 2011·Oncogene·D N ChurchA B Hassan
May 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Karen A BoehmeChristine Blattner
Jul 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Annarita Di LorenzoWilliam C Sessa
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kajsa EricsonNickolas Papadopoulos
Sep 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xiaofei SunSudhansu K Dey
Jun 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Alicia ArranzChristos Tsatsanis
Feb 9, 2011·The Journal of Biological Chemistry·Qisheng TuJake Chen
Oct 15, 2010·The Journal of Biological Chemistry·Scott A SoleimanpourDoris A Stoffers
Feb 16, 2011·The Journal of Biological Chemistry·You-Tong WuBing Su
Jul 14, 2012·The Journal of Biological Chemistry·Yuanshu DongZhong-Yin Zhang
Sep 2, 2008·The Journal of Biological Chemistry·Banu SurucuBrian A Hemmings
Feb 10, 2011·Antioxidants & Redox Signaling·Lan ZhangDavid Wan-Cheng Li
Jul 20, 2012·Molecular Biology of the Cell·Reetta VirtakoivuJohanna Ivaska
Dec 17, 2010·Human Molecular Genetics·Satoko TokudaWayne N Frankel
Aug 30, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Rachel RogersMary Hixon
Feb 21, 2009·Biology of Reproduction·Amanda N Sferruzzi-PerriSarah A Robertson
Oct 29, 2010·Biology of Reproduction·Vicki PlaksAlon Harmelin
May 13, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Theodora M MauroDavid Pearce
Jan 24, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hong Wa YungGraham J Burton
Sep 20, 2006·Molecular and Cellular Biology·Lisa Héron-MilhavetNed J C Lamb
May 12, 2010·Molecular and Cellular Biology·Qiuting FengZhongzhou Yang
Nov 26, 2009·Molecular and Cellular Biology·Francesca BuzziMarkus Niessen
Aug 23, 2006·Molecular and Cellular Biology·Bettina DummlerBrian A Hemmings
Oct 13, 2006·Molecular and Cellular Biology·Don BenjaminChristoph Moroni
Mar 19, 2008·Molecular and Cellular Biology·Jose R BayascasDario R Alessi
Sep 29, 2011·Molecular and Cellular Biology·Lindsey N KentMichael J Soares
Nov 17, 2005·Molecular and Cellular Biology·Zhong-Zhou YangBrian A Hemmings
Feb 17, 2005·Molecular and Cellular Biology·Nicolas Di-PoïWalter Wahli
Feb 17, 2005·Molecular and Cellular Biology·Rachael M EastonMorris J Birnbaum
Apr 4, 2006·Molecular and Cellular Biology·Karim NadraBéatrice Desvergne
Sep 16, 2008·Molecular Cancer Therapeutics·Daruka MahadevanEmmanuelle J Meuillet
Oct 29, 2009·Molecular Cancer Research : MCR·Shannon P FortinNhan L Tran
Jan 26, 2008·Hormone Research·Karen Forbes, Melissa Westwood
Jul 12, 2005·The Journal of Clinical Investigation·Tomohisa NagoshiAnthony Rosenzweig
Aug 3, 2005·The Journal of Clinical Investigation·Eric AckahWilliam C Sessa
Dec 8, 2010·The Journal of Clinical Investigation·Mayumi MoriToru Miyazaki
Jan 10, 2012·Reproductive Sciences·Sung Tae KimKelle H Moley
Sep 16, 2010·BMC Developmental Biology·Lindsey N KentMichael J Soares
Jul 30, 2011·Skeletal Muscle·Stefano Schiaffino, Cristina Mammucari