Protein kinase C activation decreases activity-dependent attenuation of dendritic Na+ current in hippocampal CA1 pyramidal neurons

Journal of Neurophysiology
C M Colbert, D Johnston

Abstract

Action potentials recorded from the soma of CA1 pyramidal neurons remain relatively uniform in amplitude during repetitive firing. In contrast, the amplitudes of back-propagating action potentials in dendrites decrease progressively during a spike train. This activity-dependent decrease in amplitude is dependent on the frequency of firing during the train and distance from the soma. Previously, we described a property of Na+ channels that provides a plausible mechanism for the activity dependence of the amplitude of the dendritic action potentials: available Na+ current decreases during trains of action potentials through an inactivation, distinct from fast inactivation, that appears rapid in onset, but slow and voltage-dependent in its recovery. In this study we found that activation of protein kinase C by phorbol esters decreased this activity-dependent inactivation of pharmacologically isolated Na+ current in cell-attached dendritic, but not somatic, patches. Similarly in whole cell recordings phorbol esters decreased the attenuation of back-propagating dendritic action potentials during trains. These results indicate a novel effect of protein kinase C on the dendritic Na+ channel and further support the hypothesis that the ...Continue Reading

References

Jun 1, 1993·Pflügers Archiv : European journal of physiology·G J StuartB Sakmann
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E KlannJ D Sweatt

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Citations

May 15, 2010·Science·Andrea Lorincz, Zoltan Nusser
Aug 29, 2012·Annals of Neurology·Elena IsaevaGregory L Holmes
May 11, 2005·Journal of Neurobiology·Andreas Frick, Daniel Johnston
Jan 20, 2004·Nature Neuroscience·Andreas FrickDaniel Johnston
May 20, 1999·The Journal of Comparative Neurology·L Maler, M T Hincke
Aug 25, 2001·Annual Review of Neuroscience·A Reyes
Apr 9, 2008·Physiological Reviews·P Jesper SjöströmMichael Häusser
Dec 4, 2001·Journal of Neurophysiology·N L GoldingN Spruston
Jan 23, 1999·Journal of Neurophysiology·D A Hoffman, D Johnston
Jul 8, 1999·Current Opinion in Neurobiology·D JohnstonJ C Magee
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jul 1, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Paul A WadsworthFernanda Laezza
Apr 29, 1998·Annual Review of Physiology·J MageeD Johnston
Dec 14, 1999·Learning & Memory·V Sourdet, D Debanne
Nov 20, 2021·PloS One·Travis M RottermanTimothy C Cope

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