Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C

Neurosurgery
W T CouldwellV W Yong

Abstract

The proliferation rates of gliomas may be modulated by the protein kinase C (PKC) signal transduction system. The present study was undertaken to further examine the role of PKC system in growth regulation of gliomas in vitro by measurement of PKC activity over various phases of tumor growth and by assessing its potential role as a signal transduction system induced by serum mitogens and the known glioma mitogens epidermal growth factor and fibroblast growth factor. All human glioma lines examined, and the rat glioma C6, displayed high PKC activity relative to nonmalignant glial cells, which correlated with their proliferation rates over their respective growth phase. Frozen surgical human malignant glioma specimens also displayed high PKC activity. The relatively selective PKC inhibitor staurosporine (SP) reduced PKC activity and corresponding growth rates in a dose-related manner. Stimulation of PKC with phorbol esters under different concentrations of serum in the growth medium indicated that the high PKC activity, which correlated with their rapid growth rates, is highly susceptible to down-regulation by these agents. Epidermal growth factor and fibroblast growth factor increased both PKC activity and the growth rate of gli...Continue Reading

References

Jan 1, 1991·Journal of Neuropathology and Experimental Neurology·V W YongS U Kim
Dec 1, 1990·Journal of Neuroscience Research·J L GrossD L Dexter
Jul 18, 1986·Science·Y Nishizuka
Mar 13, 1986·Biochemical and Biophysical Research Communications·T TamaokiF Tomita
Apr 18, 1986·Science·W D Carey, J T Ratchford

❮ Previous
Next ❯

Citations

Jul 13, 2001·Cell Biology International·N V ShirsatA Mehta
Oct 1, 1996·Clinical & Experimental Metastasis·J H UhmV W Yong
Jan 1, 1995·Journal of Neuro-oncology·A J YatesJ Van Brocklyn
May 1, 1993·Journal of Neuro-oncology·G H BaltuchV W Yong
Mar 30, 2011·Targeted Oncology·Nicole A Shonka
May 5, 2001·Brain Research. Brain Research Reviews·M Bredel
Sep 24, 1998·Clinical Neurology and Neurosurgery·L MastronardiA Ruggeri
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K K ChoM L Rosenblum
Oct 3, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A B da RochaG Schwartsmann
Jun 1, 1997·Antisense & Nucleic Acid Drug Development·R I Glazer
Dec 21, 2004·Journal of Neurochemistry·Madhavi S Moodbidri, Neelam V Shirsat
Jun 10, 2000·Molecular and Cellular Biology·A Besson, V W Yong
Oct 1, 1994·Neurosurgery·W T CouldwellR E Law
May 24, 2003·Neurosurgery·Gurpreet S Kapoor, Donald M O'Rourke
Dec 2, 2014·Neurosurgical Focus·Darryl LauManish K Aghi
Jun 22, 2005·Neoplasia : an International Journal for Oncology Research·Chengkai DaiEric C Holland
Mar 26, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K S OpstadF A Howe
Jan 7, 2006·Photochemistry and Photobiology·Silvia KocanovaPavol Miskovsky
May 26, 2005·Brain Research. Brain Research Reviews·Lyle W Ostrow, Frederick Sachs
May 13, 2015·Biochimica Et Biophysica Acta·Samy A F Morad, Myles C Cabot
Mar 4, 2014·Photodiagnosis and Photodynamic Therapy·Lenka DzurováKatarina Stroffekova
Feb 1, 2000·Toxicology and Applied Pharmacology·M WeiL G Costa
Mar 1, 1995·Journal of Neurosurgery·W T CouldwellD R Hinton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.