Protein kinase C is involved in resistance to myocardial infarction induced by heat stress

Journal of Molecular and Cellular Cardiology
M JoyeuxD M Yellon

Abstract

Heat stress (HS) is known to protect against mechanical dysfunction and myocardial necrosis in myocardial ischemia-reperfusion models both in vivo and in vitro. However, the mechanisms involved in this form of cardioprotection remain unclear. Protein kinase C (PKC) and tyrosine kinase activation have both been shown to be involved in the delayed phase of protection following ischemic preconditioning, a phenomenon which appears to be analogous to HS-induced protection. Therefore, we investigated the role of PKC and tyrosine kinase in HS-induced resistance to myocardial infarction, in the isolated rat heart. The selective inhibitors chelerythrine (Che) and genistein (Gen) were used to inhibit PKC and tyrosine kinase, respectively. Rats were treated with Che (5 mg/kg, i.p.) or Gen (5 mg/kg, i.p.) or vehicle before they were either heat stressed (42 degrees C for 15 min) or sham anesthetized. Twenty-four h later their hearts were isolated, retrogradely perfused, and subjected to 35-min occlusion of the left coronary artery followed by 120-min of reperfusion. Infarct-to-risk ratio was significantly reduced in HS (19.9+/-1.1%) compared to sham (43.1+/-1.1%) hearts. This reduction in infarct size was abolished in chelerythrine-treated...Continue Reading

Citations

Jun 12, 2004·Current Atherosclerosis Reports·Donald B DeFrancoClifton W Callaway
Aug 1, 2008·Cell Stress & Chaperones·C W James MellingEarl G Noble
Jun 24, 2003·Journal of Molecular and Cellular Cardiology·Kunitoshi YamanakaTetsunori Saikawa
May 18, 1999·International Journal of Cardiology·R Carroll, D M Yellon
Dec 1, 1998·British Journal of Pharmacology·M JoyeuxC Ribuot
Feb 23, 1999·Fundamental & Clinical Pharmacology·M JoyeuxC Ribuot
Apr 20, 2012·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Hans ReineckeCharles E Murry
Nov 25, 2000·Circulation Research·R Bolli
Oct 27, 2005·Journal of Biomechanical Engineering·Marissa Nichole RylanderShanti J Aggarwal
Jan 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sonya D CoaxumRuben Mestril
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·D TekinR C Kukreja
Jan 13, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Guohu LiLubo Zhang
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J J ZhouT M Wong
Apr 13, 1999·The American Journal of Physiology·R M FryerG J Gross
Jul 17, 2007·Cellular Signalling·Micheal E BarnettDolores J Takemoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.