Protein kinase C modulates ecdysteroidogenesis in the prothoracic gland of the tobacco hornworm, Manduca sexta

Molecular and Cellular Endocrinology
R Rybczynski, Lawrence I Gilbert

Abstract

The prothoracic gland is the primary source of ecdysteroid hormones in the immature insect. Ecdysteroids coordinate gene expression necessary for growth, molting and metamorphosis. Prothoracicotropic hormone (PTTH), a brain neuropeptide, regulates ecdysteroid synthesis in the prothoracic gland. PTTH stimulates ecdysteroid synthesis through a signal transduction cascade that involves at least four protein kinases: protein kinase A (PKA), p70 S6 kinase, an unidentified tyrosine kinase, and the extracellular signal-regulated kinase (ERK). In this report, the participation of protein kinase C (PKC) in PTTH signalling is demonstrated and characterized. PTTH stimulates PKC activity through a PLC and Ca(2+)-dependent pathway that is not cAMP regulated. Inhibition of PKC inhibits PTTH-stimulated ecdysteroidogenesis as well as PTTH-stimulated phosphorylation of ERK and its upstream regulator, MAP/ERK kinase (MEK). These observations reveal that the acute regulation of prothoracic gland steroidogenesis is dependent on a web of interacting kinase pathways, which probably converge on factors that regulate translation.

References

Dec 3, 1990·Molecular and Cellular Endocrinology·V H Meller, L I Gilbert
Jan 1, 1996·Annual Review of Pharmacology and Toxicology·T GudermannG Schultz
Jul 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J Hofmann
Apr 30, 1998·Advances in Cancer Research·T S LewisN G Ahn
Jun 26, 1998·The Biochemical Journal·H Mellor, P J Parker
Apr 3, 1999·Cellular and Molecular Life Sciences : CMLS·C HöllerC Nanoff
Feb 17, 2000·The EMBO Journal·D B ParekhP J Parker
Aug 6, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C MaaschH Haller
Aug 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·E C DempseyR O Messing
Sep 29, 2000·Progress in Nucleic Acid Research and Molecular Biology·S Volarević, G Thomas
Jun 8, 2001·Annual Review of Biochemistry·S G Rhee
Nov 6, 2001·Molecular and Cellular Endocrinology·R RybczynskiL I Gilbert
Dec 1, 2001·Annual Review of Entomology·Lawrence I GilbertJames T Warren
Aug 2, 2002·The Journal of Biological Chemistry·Hui ZhangMichael J Comb
Oct 3, 2002·Journal of Biochemistry·Bih-Hwa ShiehDaniela Popescu
Dec 24, 2002·The Biochemical Journal·Alexandra C Newton
Dec 21, 2004·Molecular and Cellular Endocrinology·Jennifer Priester, Wendy A Smith
Oct 19, 2005·Nature Reviews. Molecular Cell Biology·Craig C Malbon

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Citations

Feb 1, 1997·Nature Biotechnology·J J EstruchM G Koziel
Jul 1, 2011·Genes & Development·Lucía CáceresHenry M Krause
Dec 1, 2009·PloS One·Takehiko OguraTakahiro Shiotsuki
Jan 17, 2016·Insect Biochemistry and Molecular Biology·David A McKinneyMark R Brown
Jan 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yuya OhharaSatoru Kobayashi
May 9, 2009·Insect Biochemistry and Molecular Biology·Kim F RewitzLawrence I Gilbert
Feb 26, 2009·Archives of Insect Biochemistry and Physiology·Robert RybczynskiSho Sakurai
Dec 20, 2014·Insect Biochemistry and Molecular Biology·Shi-Hong Gu, Yun-Chin Hsieh
Oct 16, 2008·Developmental Cell·Sophie LayallePierre Léopold
Dec 3, 2010·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Sony ShresthaYonggyun Kim
Nov 23, 2019·Insect Biochemistry and Molecular Biology·Shi-Hong Gu, Chien-Hung Chen
May 1, 2021·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Shi-Hong GuPei-Ling Lin
Sep 3, 2009·Peptides·Elisabeth MarchalJozef Vanden Broeck

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