PMID: 2110069Apr 9, 1990Paper

Protein kinase C-regulated production of prostacyclin by rat endothelium is increased in the presence of lipoxin A4

FEBS Letters
D Leszczynski, J Ustinov

Abstract

Prostacyclin is generated by cultured rat endothelial cells. Compound blocking activity of protein kinase C and cyclic nucleotide-dependent protein kinases (H7) and compound blocking interaction between Ca2+ and calmodulin (W7) diminish generation of prostacyclin in rat endothelial cells. These compounds give a synergistic effect when they are introduced to the endothelial cell cultures simultaneously. Compound HA1004, an inhibitor of cAMP- and cGMP-dependent protein kinases has no effect on prostacyclin generation. Lipoxin A4, a potent direct stimulator of protein kinase C, rapidly induces prostacyclin generation in rat endothelium in a dose- and time-dependent fashion. Lipoxin A4-induced generation of prostacyclin can be inhibited by H7 and W7 but not by HA1004. Lipoxin B4 has no significant effect on prostacyclin generation in rat endothelium. In conclusion, our results demonstrate that generation of prostacyclin by rat endothelial cells is regulated via a pathway involving protein kinase C and Ca2+.

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Citations

Apr 14, 1994·Biochimica Et Biophysica Acta·C N Serhan
Oct 1, 1995·Journal of Lipid Mediators and Cell Signalling·C N Serhan, M Romano
Apr 17, 2004·Kidney International·Niamh E KieranCatherine Godson
Jun 1, 1995·Photodermatology, Photoimmunology & Photomedicine·D LeszczynskiK Servomaa
Aug 31, 2006·Prostaglandins & Other Lipid Mediators·Octavio Menezes-de-LimaJoão B Calixto
Apr 27, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·I M Fierro, C N Serhan
Dec 26, 2002·The Journal of Biological Chemistry·Caroline BonnansValerie Urbach
Oct 14, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yael GrumbachValérie Urbach
Jul 28, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Youjia DuPeter Zahradka
Jul 12, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Charles N Serhan

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