Protein kinase C zeta regulates interleukin-8-mediated stromal-derived factor-1 expression and migration of human mesenchymal stromal cells

Experimental Cell Research
Sonia C PicinichDebabrata Banerjee

Abstract

Mesenchymal stromal cells (MSCs) are bone marrow-derived cells with multipotent differentiation capability that are mobilized into the circulation in response to injury and localize to areas of tissue damage including solid tumors. They have the capacity to adopt a phenotype similar to carcinoma-associated fibroblasts (CAFs) and, like CAFs, promote tumor growth. The molecular communication between tumor cells and MSCs has not been well defined. However, MSCs have increased expression of the chemokine stromal-derived factor 1 (SDF-1) when exposed to conditioned medium from tumor cells. Additionally, SDF-1 has been shown to be important in the promotion of tumor growth by CAFs. These data suggest that the SDF-1 signaling axis is a key feature of the tumor microenvironment. In this report, we demonstrate that interleukin 8 (IL-8) induces an increase in SDF-1 expression by MSCs. The increase in SDF-1 expression in response to IL-8 is mediated by the activation of the protein kinase C (PKC) zeta isoform. In a functional assay, activation of PKC is required for in vitro MSC migration in response to tumor conditioned medium. These results indicate that IL-8-mediated SDF-1 production by MSCs requires PKC zeta activation. This signaling...Continue Reading

Citations

Dec 18, 2015·Scientific Reports·Alexander KuettMichael Fiegl
Jul 21, 2011·Journal of Tissue Engineering and Regenerative Medicine·Anja GoedeckeMartin Bornhauser
Oct 12, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Juan BayoGuillermo Mazzolini
Apr 28, 2016·Experimental Hematology·Christina T Rieger, Michael Fiegl
Mar 21, 2017·Stem Cells·Franziska NitzscheJohannes Boltze
Dec 12, 2018·Canadian Journal of Gastroenterology & Hepatology·Shan WangJinzhou Zhang
Feb 12, 2020·Journal of Clinical Medicine·Gonzalo José Jimenez-PuertaPatricia Gálvez-Martín
Mar 19, 2021·Journal of Periodontal Research·Sema S HakkiSeyit Ali Kayis

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