Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer

Frontiers in Pharmacology
Tina HorbachElitsa Y Dimova

Abstract

The upstream stimulatory factors (USFs) are regulators of important cellular processes. Both USF1 and USF2 are supposed to have major roles in metabolism, tissue protection and tumor development. However, the knowledge about the mechanisms that control the function of USFs, in particular in tissue protection and cancer, is limited. Phosphorylation is a versatile tool to regulate protein functions. Thereby, phosphorylation can positively or negatively affect different aspects of transcription factor function including protein stability, protein-protein interaction, cellular localization, or DNA binding. The present review aims to summarize the current knowledge about the regulation of USFs by direct phosphorylation and the consequences for USF functions in tissue protection and cancer.

References

Jul 2, 1992·Nature·D P Lane
Apr 20, 1994·Gene·S A MarlowJ M Papadimitriou
Apr 1, 1993·Current Opinion in Genetics & Development·A D Baxevanis, C R Vinson
Jul 20, 1995·Genomics·E SteingrímssonN A Jenkins
Jan 19, 1996·The Journal of Biological Chemistry·B ViolletA Martinez
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·X Luo, M Sawadogo
Apr 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·G Casabona
Jul 1, 1997·The EMBO Journal·H AberleR Kemler
Aug 29, 1997·The Journal of Biological Chemistry·V S ValletS Vaulont
Feb 14, 1998·Cancer Genetics and Cytogenetics·N N NupponenT Visakorpi
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M SiritoM Sawadogo
Oct 19, 1999·Oncogene·P M IsmailM Sawadogo
Nov 11, 1999·Oncogene·P L DavisJ R Marks
Oct 12, 2000·Cellular and Molecular Life Sciences : CMLS·A J Bannister, E A Miska
Oct 12, 2000·Cellular and Molecular Life Sciences : CMLS·J M DesterroR T Hay
Aug 31, 2001·Progress in Neurobiology·C A Grimes, R S Jope
Sep 21, 2001·The Biochemical Journal·S Frame, P Cohen
Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Qianxun XiaoKaie Ojamaa

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Citations

Jan 13, 2018·Endocrine-related Cancer·Daniely Regina Freitas-AlvesRosane Vianna-Jorge
Nov 19, 2020·Proceedings of the National Academy of Sciences of the United States of America·Dan HuHoward L Weiner
Oct 16, 2020·Redox Biology·Tabughang Franklin ChiElitsa Y Dimova
Sep 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Neeraj AgarwalDan Theodorescu

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Methods Mentioned

BETA
acetylation
ChIP-chip
xenograft
transfection
nuclear translocation

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