Protein levels of ADAM10, BACE1, and PSEN1 in platelets and leukocytes of Alzheimer's disease patients

European Archives of Psychiatry and Clinical Neuroscience
Jessyka Maria de França BramOrestes V Forlenza

Abstract

The clinical diagnosis of Alzheimer's disease (AD) is a probabilistic formulation that may lack accuracy particularly at early stages of the dementing process. Abnormalities in amyloid-beta precursor protein (APP) metabolism and in the level of APP secretases have been demonstrated in platelets, and to a lesser extent in leukocytes, of AD patients, with conflicting results. The aim of the present study was to compare the protein level of the APP secretases A-disintegrin and metalloprotease 10 (ADAM10), Beta-site APP-cleaving enzyme 1 (BACE1), and presenilin-1 (PSEN1) in platelets and leukocytes from 20 non-medicated older adults with AD and 20 healthy elders, and to determine the potential use of these biomarkers to discriminate cases of AD from controls. The protein levels of all APP secretases were significantly higher in platelets compared to leukocytes. We found statistically a significant decrease in ADAM10 (52.5%, p < 0.0001) and PSEN1 (32%, p = 0.02) in platelets from AD patients compared to controls, but not in leukocytes. Combining all three secretases to generate receiver-operating characteristic (ROC) curves, we found a good discriminatory effect (AD vs. controls) when using platelets (the area under the curve-AUC-0....Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jan 1, 1980·Journal of Neural Transmission. Supplementum·A Pletscher, A Laubscher
Jun 9, 1995·The Journal of Biological Chemistry·Q X LiC L Masters
Feb 1, 1997·Archives of Neurology·R N RosenbergM F Weiner
Jul 12, 2002·Annals of Neurology·R M Damian HolsingerGeneviève Evin
Sep 12, 2002·Archives of Neurology·Hiroaki FukumotoMichael C Irizarry
Jan 7, 2003·Genes & Development·Darren F Seals, Sara A Courtneidge
Jan 25, 2003·Experimental Gerontology·Marco Racchi, Stefano Govoni
Nov 5, 2003·Journal of Neuroscience Research·Geneviève EvinQiao-Xin Li
Dec 14, 2004·The Journal of Biological Chemistry·Anja CapellChristian Haass
Nov 1, 2005·Journal of the Neurological Sciences·Kun TangRoger N Rosenberg
Apr 15, 2006·Clinical Chemistry·Jan H VerheijenRoeland Hanemaaijer
Jul 11, 2007·European Journal of Pediatrics·Kathleen FresonChris Van Geet
Sep 22, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Breno S O DinizOrestes Vicente Forlenza
Apr 9, 2008·Current Alzheimer Research·Sarah L Cole, Robert Vassar
Aug 13, 2008·Archives of Neurology·Henrik ZetterbergKaj Blennow
Sep 3, 2008·Molecular Aspects of Medicine·Dylan R EdwardsCaroline J Pennington
Dec 4, 2008·Seminars in Cell & Developmental Biology·Karina Reiss, Paul Saftig
Dec 9, 2009·Journal of Neurochemistry·Rachel R AhmedM Paul Murphy
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Feb 19, 2010·Journal of Alzheimer's Disease : JAD·Sandra D MulderRobert Veerhuis
Sep 18, 2010·Journal of Alzheimer's Disease : JAD·Roberta BorghiMassimo Tabaton
Mar 16, 2011·Journal of Alzheimer's Disease : JAD·Boris Decourt, Marwan N Sabbagh

❮ Previous
Next ❯

Citations

Oct 24, 2018·Blood·Samantha J MontagueElizabeth E Gardiner
May 20, 2019·Journal of Alzheimer's Disease : JAD·Richard J Elsworthy, Sarah Aldred
Oct 31, 2020·Frontiers in Immunology·Mikhail InyushinLilia Kucheryavykh
Feb 6, 2021·The International Journal of Neuroscience·Hongyun QinBinggen Zhu
Nov 9, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sajad NajafiShahin Aghamiri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Related Papers

Journal of Alzheimer's Disease : JAD
Tamires Alves SarnoOrestes V Forlenza
Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Robert PerneczkyAlzheimer's Disease euroimaging Initiative
Scandinavian Journal of Clinical and Laboratory Investigation
H Zetterberg
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
Hao LiYun Wei
© 2022 Meta ULC. All rights reserved