Protein-losing pseudomembranous colitis with cap polyposis-like features

World Journal of Gastroenterology : WJG
Wolfgang KreiselAnnette Schmitt-Graeff

Abstract

Protein-losing enteropathy (PLE) is characterized by loss of serum proteins into the gastrointestinal tract. It may lead to hypoproteinemia and clinically present as protein deficiency edema, ascites, pleural or pericardial effusion and/or malnutrition. In most cases the site of protein loss is the small intestine. Here we present an unusual case of severe PLE in a 55-year old female with a one-year history of recurrent diarrhea, crampy abdominal pain, and peripheral edema. Endoscopy and MRI showed a diffuse inflammatory thickening of the sigmoid colon and the rectum. Surgical resection of the involved colon was performed and the symptoms were significantly resolved. The final histologic evaluation confirmed a diagnosis of a pseudomembranous colitis with cap polyposis-like features. Such a cause of PLE has never been described before.

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Citations

Nov 15, 2018·International Journal of Colorectal Disease·Maximilian BrunnerKlaus E Matzel

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Methods Mentioned

BETA
biopsy
surgical resection

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