PMID: 15347973Sep 7, 2004Paper

Protein-mediated macrophage adhesion and activation on biomaterials: a model for modulating cell behavior

Journal of Materials Science. Materials in Medicine
W J KaoJ M Anderson

Abstract

The elucidation of proteins involved in biomaterial-modulated macrophage behavior is critical for the improvement of material performance and the initial exploration of material design capable of manipulating macrophage function for tissue engineering. In this paper, several in vitro and in vivo techniques are presented to demonstrate means of delineating a part of the complex molecular mechanisms involved in the interaction between biomaterial and macrophage adhesion and phenotypic development. The following conclusions were reached: (1) using radioimmunoassay, complement component C3 was found to be critical in mediating human macrophage adhesion on polyurethanes. (2) The presence of a diphenolic antioxidant additive in polyurethanes increased the propensity for complement upregulation but did not affect adherent macrophage density. (3) The subcutaneous cage-implant system was utilized to delineate interleukin-4 participation in the fusion of adherent macrophages to form foreign body giant cells in vivo in mice. The injection of purified interleukin-4 neutralizing antibody into the implanted cages significantly decreased the giant cell density; conversely, the giant cell density was significantly increased by the injection of...Continue Reading

Citations

Jan 13, 2012·Journal of Biomedical Materials Research. Part a·M Walkowiak-PrzybyłoB Walkowiak
Apr 10, 2002·Journal of Biomaterials Applications·Livia VisaiM Cristina Tanzi
Oct 7, 2010·Advanced Materials·Chandramouleeswaran SubramaniVincent M Rotello
Oct 30, 2013·Journal of Biomedical Materials Research. Part a·Lu HuangWei He
Aug 27, 2009·Journal of Biomedical Materials Research. Part a·Aaron D LynnStephanie J Bryant
Nov 26, 2010·Journal of Biomedical Materials Research. Part a·Peng Meng Kou, Julia E Babensee
Nov 1, 2007·Basic & Clinical Pharmacology & Toxicology·Stig S JakobsenKjeld Soballe
Aug 19, 2003·Biomaterials·Ulrich HerselHorst Kessler
Dec 18, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Haoyu WangPinar Akcora
Apr 25, 2008·Biomaterials·Sviatlana KalininaDoris Wedlich
Jan 26, 2006·Journal of the American Chemical Society·Mandana Veiseh, Miqin Zhang

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