Jun 20, 2001

Protein misfolding and disease; protein refolding and therapy

FEBS Letters
C Soto

Abstract

Diverse human disorders, including several neurodegenerative diseases and systemic amyloidosis, are thought to arise from the misfolding and aggregation of an underlying protein. Recent findings strongly support this hypothesis and have increased our understanding of the molecular mechanism of protein conformational disorders. Many questions are still pending, but the data overall suggest that correction of protein misfolding constitutes a viable therapeutic strategy for conformational diseases.

  • References36
  • Citations108

Citations

Mentioned in this Paper

Pathogenic Aspects
Abnormal Degeneration
Pathogenesis
Systemic Amyloidosis
APP protein, human
Amyloidosis
Structure-Activity Relationship
Aggregation
HTT
Brain

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