Protein-osmolality ratio for quantification of proteinuria in children.

Clinical and Experimental Nephrology
Erkin Serdaroglu, S Mir

Abstract

Proteinuria is an important factor for renal injury and prognosis in many diseases. The most valuable method for evaluation of proteinuria is quantitative protein analysis in appropriately 24-h collected urine. But urine collection is difficult and cumbersome especially in children and working adults. The aim of the present study is to define the usefulness of urinary protein/urine osmolality (Uprot/Uosm) ratio in quantification of proteinuria. One hundred and seventy-one patients whose age ranged between 3 and 14 years were included in the study. Uprot/Uosm (r = 0.85, P < 0.001) and urinary protein/creatinine Uprot/Ucrea (r = 0.81 and P < 0.001) ratios were significantly correlated with 24-h protein excretion. Twenty-four-hour protein excretion was correlated with Uprot/Ucrea (r = 0.76, P < 0.001) and Uprot/Uosm (r = 0.79, P < 0.001) ratios in proteinuric group. But, there was no correlation between Uprot/Uosm and Uprot/Ucrea ratios with 24-h protein excretion in non-proteinuric group. The positive and negative predictive value of Uprot/Uosm ratio of 0.28 mg/l/mOsm/kg was 89.9 and 90.8% and Uprot/Ucrea ratio of 0.24 mg/mg was 85.7 and 90% for estimating proteinuria (above 4 mg/m2 h(-1)). The 95th percentile of Uprot/Uosm ratio...Continue Reading

References

Dec 22, 1983·The New England Journal of Medicine·J M GinsbergS Garella
Jun 1, 1984·The Journal of Pediatrics·M Houser
Oct 1, 1993·American Journal of Clinical Pathology·D M Wilson, R L Anderson
Jul 1, 1997·Kidney International·R R MooreB L Kasiske
Feb 24, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H S KimS K Kim
Aug 10, 2002·American Journal of Nephrology·Chirag R ParikhChristos P Carvounis

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