Protein Palmitoylation in Leukocyte Signaling and Function

Frontiers in Cell and Developmental Biology
Xiaoyuan YangSarah Y Yuan

Abstract

Palmitoylation is a post-translational modification (PTM) based on thioester-linkage between palmitic acid and the cysteine residue of a protein. This covalent attachment of palmitate is reversibly and dynamically regulated by two opposing sets of enzymes: palmitoyl acyltransferases containing a zinc finger aspartate-histidine-histidine-cysteine motif (PAT-DHHCs) and thioesterases. The reversible nature of palmitoylation enables fine-tuned regulation of protein conformation, stability, and ability to interact with other proteins. More importantly, the proper function of many surface receptors and signaling proteins requires palmitoylation-meditated partitioning into lipid rafts. A growing number of leukocyte proteins have been reported to undergo palmitoylation, including cytokine/chemokine receptors, adhesion molecules, pattern recognition receptors, scavenger receptors, T cell co-receptors, transmembrane adaptor proteins, and signaling effectors including the Src family of protein kinases. This review provides the latest findings of palmitoylated proteins in leukocytes and focuses on the functional impact of palmitoylation in leukocyte function related to adhesion, transmigration, chemotaxis, phagocytosis, pathogen recognitio...Continue Reading

References

May 14, 1992·Nature·T J MolinaA Veillette
Oct 25, 1996·The Journal of Biological Chemistry·A Y TsygankovJ B Bolen
Jun 1, 1997·Molecular Biology of the Cell·A WolvenM D Resh
Jun 23, 1998·The Journal of Biological Chemistry·J A Duncan, A G Gilman
May 18, 1999·Biochemical and Biophysical Research Communications·K Vogel, P A Roche
Feb 24, 2000·The Journal of Experimental Medicine·C J Fitzer-AttasC A Lowell
Jun 8, 2001·The Journal of Biological Chemistry·Y PercherancierF Bachelerie
Jul 4, 2001·FEBS Letters·T UtsumiR Ishisaka
Oct 13, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M J van HemertG P van Heusden
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·P GuptaS L Hofmann
Apr 18, 2002·FEBS Letters·Stéphanie CharrinEric Rubinstein
Aug 24, 2002·The Journal of Biological Chemistry·Sandra LoboRobert J Deschenes
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koubun YasudaAtsushi Kosugi
Oct 9, 2002·The Journal of Cell Biology·Amy F RothNicholas G Davis
Dec 18, 2002·The Journal of Experimental Medicine·Tomás BrdickaVáclav Horejsí
Mar 4, 2003·Molecular and Cellular Biology·Dominique DavidsonAndré Veillette
Mar 19, 2003·The Journal of Biological Chemistry·Tara L BakerJanice E Buss
May 7, 2003·The Journal of Experimental Medicine·Dominik FilippMichael Julius
Nov 12, 2003·The Journal of Experimental Medicine·Eun Mi HurYungdae Yun
Feb 18, 2004·The Journal of Biological Chemistry·Krista L ClarkScott C Todd
Mar 3, 2004·BioTechniques·Renaldo C Drisdel, William N Green
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fran BalamuthKim Bottomly
May 27, 2004·The Journal of Biological Chemistry·Anu CherukuriSusan K Pierce
Aug 3, 2004·Nature Reviews. Immunology·Václav HorejsíBurkhart Schraven
Mar 9, 2005·The Journal of Biological Chemistry·Hidehiko ShogomoriDeborah A Brown
Jul 8, 2005·The Journal of Biological Chemistry·John T SwarthoutMaurine E Linder
Dec 3, 2005·Hematology·Robert Flaumenhaft, Derek S Sim
Feb 8, 2006·Biochemical and Biophysical Research Communications·Natsuko TanimuraKensuke Miyake
Apr 14, 2006·Molecular Membrane Biology·Panagiotis S Kabouridis

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Methods Mentioned

BETA
myristoylation
ubiquitination
GTPase
immunoprecipitation
X-ray
proximity ligation
acylation

Software Mentioned

CSS
GPS
Palm
lipid

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