Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation

Metabolic Brain Disease
Tao T ZhangH Y Tung

Abstract

Protein phosphatase-2A (PP-2A) interacts with several regulators of cell death pathways and is therefore a potential component of signaling pathways linking global cerebral ischemia to cell death. Using a novel procedure to quantify PP-2A activity, we find that cardiac arrest with resuscitation and reperfusion leads to activation of PP-2A by 1.6-fold in pig brain extract and by 3.4-fold after partial purification of PP-2A. This is the first demonstration of PP-2A activation in a clinically relevant model of transient global cerebral ischemia. These results suggest that inhibition of PP-2A activity may be neuroprotective in global cerebral ischemia.

References

Nov 1, 1992·Journal of Neurobiology·D W Choi
Mar 1, 1990·Trends in Biochemical Sciences·P CohenY Tsukitani
Feb 1, 1986·Annals of Neurology·S M Rothman, J W Olney
Jan 1, 1989·Annual Review of Biochemistry·P Cohen
Jan 1, 1988·Methods in Enzymology·P CohenH Y Tung
Oct 1, 1988·Critical Care Medicine·B K Siesjö
May 2, 1983·European Journal of Biochemistry·T S Ingebritsen, P Cohen
May 1, 1995·The Annals of Thoracic Surgery·B K SiesjöJ Folbergrová
Mar 3, 1994·The New England Journal of Medicine·S A Lipton, P A Rosenberg
Jan 1, 1996·Journal of Cardiothoracic and Vascular Anesthesia·D L Small, A M Buchan
Feb 23, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Shamloo, T Wieloch
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·R ShtrichmanT Kleinberger
Oct 3, 1999·Physiological Reviews·P Lipton
Feb 28, 2001·Apoptosis : an International Journal on Programmed Cell Death·T Kleinberger
Jul 20, 2002·Current Opinion in Pharmacology·Susanne Klumpp, Josef Krieglstein
Sep 5, 2002·Journal of Neuroscience Research·Cristina Martín de la VegaMatilde Salinas
Mar 7, 2003·The Journal of Biological Chemistry·Lucia CicchillittiFabio Martelli
Mar 27, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seth Love
May 6, 2003·Biochimica Et Biophysica Acta·Christine Van Hoof, Jozef Goris
Oct 31, 2003·Biochimie·Alphonse GarciaAngelita Rebollo
Aug 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rachel BrightDaria Mochly-Rosen

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