PMID: 8595878Feb 1, 1996Paper

Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila

Genes & Development
D A WassarmanG M Rubin

Abstract

Protein phosphatase 2A (PP2A), a heterotrimeric serine/threonine phosphatase present in most tissues and cell types, has been implicated in the regulation of cell cycle progression, DNA replication, transcription, and translation. Here we present genetic evidence suggesting that PP2A functions downstream of Ras1 in the Sevenless receptor tyrosine kinase (RTK) signal transduction pathway that specifies R7 photoreceptor cell fate in the developing Drosophila eye. Ras1 and downstream cytoplasmic kinases, Raf, MEK, and MAPK, comprise an evolutionarily conserved cascade that mediates the transmission of signals from RTKs at the plasma membrane to specific factors in the nucleus. Using transgenic flies expressing constitutively activated Ras1 or Raf proteins that function independently of upstream signaling events, we show that a reduction in the dose of the gene encoding the catalytic subunit of PP2A stimulates signaling from Ras1 but impairs signaling from Raf. This suggests that PP2A both negatively and positively regulates the Ras1 cascade by dephosphorylating factors that function at different steps in the cascade.

References

Jan 1, 1992·Advances in Cancer Research·G HeideckerU R Rapp
Feb 1, 1995·Current Opinion in Genetics & Development·D A WassarmanG M Rubin
Nov 1, 1994·Trends in Biochemical Sciences·G DaumU R Rapp
Jan 1, 1995·Trends in Biochemical Sciences·B M Burgering, J L Bos
Dec 1, 1994·Current Opinion in Cell Biology·T R Coleman, W G Dunphy
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·P Dent, T W Sturgill
Mar 1, 1994·Molecular Biology of the Cell·T H LeeM W Kirschner
Jan 1, 1994·Annual Review of Neuroscience·S L Zipursky, G M Rubin
Jun 1, 1993·Genes & Development·N KinoshitaM Yanagida
Aug 1, 1994·Trends in Cell Biology·R E Mayer-Jaekel, B A Hemmings
Sep 1, 1987·Developmental Biology·A Tomlinson, D F Ready

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Citations

May 14, 1999·Trends in Biochemical Sciences·T A MillwardB A Hemmings
Dec 22, 1999·The Plant Journal : for Cell and Molecular Biology·J DeruèreA Delong
Mar 4, 2009·The Journal of Biological Chemistry·Haiqin LuBih-Hwa Shieh
Feb 16, 2006·Molecular and Cellular Biology·John DaSilvaDafna Bar-Sagi
Jan 1, 1997·Annual Review of Immunology·J Alberola-IlaR M Perlmutter
Jul 27, 2011·PloS One·Márton MiskeiViktor Dombrádi
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ning WangBih-Hwa Shieh
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Adam M SilversteinMarc C Mumby
May 4, 2005·Development Genes and Evolution·Kristina Jackson BehanJohn Archie Pollock
Jun 18, 2014·FEBS Letters·Botond CsehManuela Baccarini
Jul 1, 2008·Biochimica Et Biophysica Acta·Pieter J A EichhornRené Bernards
Jan 22, 2005·Current Opinion in Genetics & Development·Veerle JanssensChristine Van Hoof
Sep 21, 2000·Seminars in Immunology·M Saxena, T Mustelin
Feb 15, 2014·Cancer Cell·Jane CullisRobert Rottapel
Jun 10, 2010·PLoS Genetics·Caline S KaramVictor G Corces

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