PMID: 6967025Jun 1, 1980Paper

Protein phosphorylation in human placenta. Stimulation by epidermal growth factor

Molecular and Cellular Endocrinology
G CarpenterL E King

Abstract

Membranes prepared from normal human term placenta possess a protein kinase activity which phosphorylates endogenous substrates in the presence of [gamma-32P]ATP. This kinase activity requires either Mg2+ or Mn2+, is enhanced by glycerol and appears to be cyclic-nucleotide-independent. Addition of epidermal growth factor to the placental membrane preparation increases the level of total phosphorylation by approx. 35%. When analyzed by sodium dodecyl sulfate gel electrophoresis and autoradiography, the placental proteins whose degree of phosphorylation was enhanced by epidermal growth factor had apparent molecular weights of 170000, 150000, and 25000. This report documents the presence of protein kinase activity in human placenta and demonstrates that epidermal growth factor can enhance protein phosphorylation in normal human tissue.

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Citations

Aug 1, 1982·Molecular and Cellular Endocrinology·R E Gates, L E King
Jul 1, 1983·Molecular and Cellular Endocrinology·G Carpenter
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L M PetruzzelliO M Rosen
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R A RubinH S Earp
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E RackerE A Blair
Nov 23, 1982·Biochemistry·J NavarroE Racker
Nov 1, 1989·Baillière's Clinical Endocrinology and Metabolism·C T Jones
Jan 1, 1983·American Journal of Reproductive Immunology : AJRI·P M Johnson, T G Wegmann
Apr 1, 1990·Journal of Endocrinological Investigation·F PetragliaS Angioni
Dec 10, 1982·Annals of the New York Academy of Sciences·G CarpenterA M Soderquist
May 1, 1982·Journal of Endocrinological Investigation·P Walker
May 22, 1984·Biochimica Et Biophysica Acta·H GalskiA A Hochberg
Feb 1, 1987·Archives of Biochemistry and Biophysics·S NakamuraE Racker
May 31, 1983·Biochemical and Biophysical Research Communications·R E Gates, L E King
Mar 15, 1982·Biochemical and Biophysical Research Communications·R E Gates, L E King
Sep 1, 1984·Placenta·B Cemerikic-Jekic, M Pavlovic-Hournac

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