Protein-Polymer Delivery: Chemistry from the Cold Chain to the Clinic

Bioconjugate Chemistry
Raymond P WelchJeremiah J Gassensmith

Abstract

Drug delivery is commonly thought of as the performance of a drug in vivo. Rather, the process of drug delivery can comprise of the journey of the drug from manufacturer to clinic, clinic to patient, and patient to disease. Each step of the journey includes hurdles that must be overcome for the therapeutic to be successful. Recent developments in proteinaceous therapeutics have made the successful completion of this journey even more important because of the relatively fragile nature of proteins in a drug delivery context. Polymers have been demonstrated to be an effective complement to proteinaceous therapeutics throughout this journey owing to their flexibility in design and function. During transit from manufacturer to clinic, the proteinaceous drug is threatened by denaturation at elevated temperatures. Polymers can help improve the thermal stability of the drug at ambient shipping conditions, thereby reducing the need for an expensive cold chain to preserve its bioactivity. Upon arrival at the clinic, the drug must be reconstituted into a suitable formulation that can be introduced into the patient. Unfortunately, traditional drug formulations relying on oral administration are generally not suitable for proteinaceous drug...Continue Reading

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Citations

Apr 16, 2020·Nanoscale·Candace E BenjaminJeremiah J Gassensmith
Jan 2, 2020·Supramolecular Chemistry·Michael A LuzuriagaJeremiah J Gassensmith
Aug 25, 2020·Advances in Pharmacological and Pharmaceutical Sciences·Dewi Melani Hariyadi, Nazrul Islam
Feb 10, 2021·ACS Biomaterials Science & Engineering·Laura J MacdougallKristi S Anseth
May 4, 2021·Chemical Reviews·Santiago CorreaEric A Appel
Jun 29, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Michael A LuzuriagaJeremiah J Gassensmith
Feb 20, 2019·ACS Applied Materials & Interfaces·Michael A LuzuriagaJeremiah J Gassensmith
May 3, 2019·Bioconjugate Chemistry·Yingqin Hou, Hua Lu
Sep 14, 2021·ACS Biomaterials Science & Engineering·Catherine M MeisEric A Appel
Sep 23, 2021·Journal of the American Chemical Society·Arezoo ShahrivarkevishahiJeremiah J Gassensmith

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