Protein-Protein Interactions: Emerging Oncotargets in the RAS-ERK Pathway

Trends in Cancer
Rocío García-GómezPiero Crespo

Abstract

Given the implication of aberrant RAS-extracellular signal-regulated kinase (ERK) signaling in the development of a large number of tumor types, this route is under intense scrutiny to identify new anticancer drugs. Most avenues in that direction have been primarily focused on the inhibition of the catalytic activity of the kinases that participate in this pathway. Although promising, the efficacy of these therapies is short lived due to undesired toxicity and/or drug resistance problems. As an alternative path, new efforts are now being devoted to the targeting of protein-protein interactions (PPIs) involved in the flow of RAS-ERK signals. Many of these efforts have shown promising results in preclinical models. In this review, we summarize recent progress made in this area.

Citations

Mar 14, 2019·Expert Reviews in Molecular Medicine·Angeliki Vogiatzi, George Mavrothalassitis
Apr 13, 2019·Endocrine-related Cancer·Miguel A ZaballosPilar Santisteban
Nov 1, 2018·Science Signaling·Eugenio Santos, Piero Crespo
Feb 28, 2020·Experimental and Therapeutic Medicine·Yan-Jun GuoLing-Ling Hu
Nov 26, 2019·Current Drug Targets·Hugo Jefferson FerreiraLuiz Gonzaga do Nascimento Neto
Oct 31, 2019·Cancer Research·Guo ChenXingming Deng
Mar 13, 2021·Structure·Mingzhen ZhangRuth Nussinov
May 1, 2021·Proceedings of the National Academy of Sciences of the United States of America·Seong Ho HongParamjit S Arora
May 8, 2020·ACS Chemical Biology·Daniel Y YooParamjit S Arora
Sep 2, 2021·Biophysics Reviews·Ruth NussinovHyunbum Jang

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