Protein-protein interactions: inhibition of mammalian carbonic anhydrases I-XV by the murine inhibitor of carbonic anhydrase and other members of the transferrin family

Journal of Medicinal Chemistry
Serdar DurdagiClaudiu T Supuran

Abstract

The murine inhibitor of carbonic anhydrase (mICA), a member of the transferrin (TF) superfamily of proteins, together with human holo- and apoTF and lactoferrin (LF) were assessed as inhibitors of all catalytically active mammalian (h = human, m = murine) CA isoforms, from CA I to CA XV. mICA was a low nanomolar to subnanomolar inhibitor of hCAs I, II, III, VA, VB, VII and mCAs XV (K(I) of 0.7-44.0 nM) and inhibited the remaining isoforms with K(I) of 185.5-469 nM. hTF, apoTF, and hLF were inhibitors of most of these CAs but with reduced efficiency compared to mICA (K(I) of 18.9-453.8 nM). Biacore surface plasmon resonance and differential scanning calorimetry experiments were also used for obtaining more insights into the interaction between these proteins, which may be useful for drug design of protein-based CA inhibitors.

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Citations

May 15, 2013·Journal of Medicinal Chemistry·Fei YuDemin Zhou
Dec 2, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Claudiu T Supuran
Feb 24, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·F Zehra KüçükbayClaudiu T Supuran
Apr 15, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Burhanettin TuranClaudiu T Supuran
Oct 27, 2016·Expert Opinion on Drug Discovery·Claudiu T Supuran
Mar 28, 2017·Bioorganic & Medicinal Chemistry·Yeganeh Entezari HeraviClaudiu T Supuran
Mar 21, 2017·Bioorganic & Medicinal Chemistry·Menshawy A MohamedClaudiu T Supuran
Mar 30, 2017·Bioorganic & Medicinal Chemistry·Fabrizio CartaClaudiu T Supuran
Feb 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela VulloClaudiu T Supuran
Dec 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Julian Mintseris, Steven P Gygi
Oct 12, 2019·Bioorganic Chemistry·Alessio NocentiniClaudiu T Supuran

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