Protein PTMs: post-translational modifications or pesky trouble makers?

Journal of Mass Spectrometry : JMS
Ralph A BradshawRobert J Chalkley

Abstract

Analysis of protein post-translational modifications using mass spectrometry is an intensive area of proteomic research. This perspective discusses the current state of the field with respect to what can be achieved, the challenges encountered, most notably with modification site assignment, the reliability of the published results, consequences of unreliable data and what is needed to be done to improve the situation.

References

Aug 23, 2005·Methods : a Companion to Methods in Enzymology·A L BurlingameRobert J Chalkley
Oct 4, 2006·Molecular & Cellular Proteomics : MCP·Michael L NielsenRoman A Zubarev
Dec 13, 2006·Current Opinion in Chemical Biology·Benjamin A GarciaDonald F Hunt

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Citations

Oct 27, 2011·Molecular & Cellular Proteomics : MCP·Jordane BiarcRalph A Bradshaw
Nov 18, 2010·Nucleic Acids Research·Florian GnadMatthias Mann
Jun 18, 2014·Journal of Proteomics·Jean-Baptiste BoyerChristine Enjalbal
Nov 9, 2010·Advances in Enzyme Regulation·Jordane BiarcRalph A Bradshaw
Jun 19, 2012·Journal of Mass Spectrometry : JMS·Mark W Duncan
Apr 15, 2011·Molecular & Cellular Proteomics : MCP·Peter R BakerRobert J Chalkley
Aug 2, 2011·Molecular BioSystems·Tania GamberiPietro Amedeo Modesti

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