Protein release kinetics of a biodegradable implant for fracture non-unions

Biomaterials
C M AgrawalB D Boyan

Abstract

Non-union of long bone fractures is often a serious complication of fracture healing. It is estimated that 100 000 non-unions occur in the united States annually and result in the loss of function of the involved limb. The present study was performed to develop a microporous polylactic acid-polyglycolic acid (PLA-PGA) implant for the delivery of bone morphogenetic protein (BMP) to sites of fracture non-unions, and to characterize the protein release kinetics of such an implant in vitro. A 50:50 copolymer of PLA-PGA was used to fabricate the implants using a gel formation technique. The implants were subjected to hydrolytic degradation in phosphate-buffered saline at 37 degrees C for up to 72 d. The protein release and the polymer degradation were monitored during this time period. The release kinetics of these implants were studied using a model protein, soybean trypsin inhibitor (TI), as well as BMP. The results indicate that there is a burst release of the proteins in the initial 48 h followed by a lower elution rate. The release of both the proteins followed similar trends. The molecular weight of the polymer decreased at a faster rate compared to its mass.

References

May 1, 1990·Journal of Biomedical Materials Research·J M SchakenraadP Nieuwenhuis
Jan 1, 1990·Acta Anatomica·J P SchmitzB D Boyan
Nov 1, 1989·Journal of Biomedical Materials Research·J M SchakenraadJ Feijen
Jan 1, 1989·Journal of Orthopaedic Trauma·E M Younger, M W Chapman
Mar 1, 1987·Missouri Medicine·R W Gaines, K J Frederick
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M R UristR J DeLange
Jul 1, 1981·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·B J Baum

❮ Previous
Next ❯

Citations

Sep 19, 1997·Journal of Biomedical Materials Research·C M AgrawalR C Schenck
Jul 1, 1997·Journal of Biomedical Materials Research·C M Agrawal, K A Athanasiou
Jun 5, 1999·Journal of Biomedical Materials Research·P X Ma, R Zhang
Aug 28, 2001·Journal of Biomedical Materials Research·Y LiuK de Groot
Jul 11, 2007·Journal of Materials Science. Materials in Medicine·Tal ReinerIrena Gotman
Mar 1, 2012·Journal of Materials Science. Materials in Medicine·Jasmin Hum, Aldo R Boccaccini
Apr 16, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Zahra GhalanborRoland Bodmeier
Apr 18, 2003·Biomaterials·Naoto Saito, Kunio Takaoka
Sep 30, 1999·Biomaterials·E M SantosP Ducheyne
Mar 6, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·J SohierJ M Bezemer
Sep 1, 2000·Advanced Drug Delivery Reviews·C A Kirker-Head
Jul 7, 2012·Tissue Engineering. Part B, Reviews·Lonnissa H NguyenAli Khademhosseini
Jan 15, 2005·Journal of Biomaterials Science. Polymer Edition·Ki Woo ChunTae Gwan Park
Dec 26, 2015·Journal of Materials Science. Materials in Medicine·Krzysztof FicekStanislaw Blazewicz
Mar 14, 2003·Journal of Biomedical Materials Research. Part a·Christopher NiedhartChristian H Siebert
Mar 25, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·C M AlvesC M Agrawal
Nov 5, 2005·Journal of Biomedical Materials Research. Part a·Jennifer G DellingerRussell D Jamison
Mar 23, 2005·Pathologie-biologie·M-C DegatD Logeart-Avramoglou
Apr 9, 2005·Macromolecular Bioscience·Andrey KovalchukMatthias Epple
Aug 5, 2010·Foot and Ankle Clinics·Siddhant K MehtaSheldon S Lin
Jan 16, 2008·Journal of Biomaterials Applications·Uwe MausChristian H Siebert
Apr 22, 2015·The Open Biomedical Engineering Journal·X LinY Liu
Mar 20, 2001·Journal of Biomedical Materials Research·C M Agrawal, R B Ray
Jul 8, 2017·Nanomaterials·Esperanza DíazJosé Manuel Barandiarán
Jan 26, 1999·Clinical Orthopaedics and Related Research·L TielinenP Törmälä
Apr 29, 1998·Journal of Biomedical Materials Research·C J GoodwinN J Marshall
Dec 20, 2007·Oral and Maxillofacial Surgery Clinics of North America·Noah A Sandler
Nov 11, 2003·Biomacromolecules·Ann-Christine Albertsson, Indra K Varma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioremediation (ASM)

Bioremediation is the treatment and removal of harmful pollutants or contaminants through the use of microorganisms. Discover the latest research here.

Related Papers

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
T MikiS Enomoto
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
A BalamuruganS Rajeswari
Journal of Materials Science. Materials in Medicine
Hanna TölliP Jalovaara
© 2021 Meta ULC. All rights reserved