Protein-repelling adhesive resin containing calcium phosphate nanoparticles with repeated ion-recharge and re-releases

Journal of Dentistry
Faisal D Al-QarniHockin H K Xu

Abstract

The objectives were to develop a calcium (Ca) and phosphate (P) ion-rechargeable and protein-repellent adhesive containing nanoparticles of amorphous calcium phosphate (NACP) and 2-methacryloyloxyethyl phosphorylcholine (MPC), and investigate the MPC effects on ion recharge and re-releases for the first time. Pyromellitic glycerol dimethacrylate and ethoxylated bisphenol-A dimethacrylate were used to fabricate adhesive PEHB. Six adhesives were tested: (1) Scotchbond (SBMP); (2) PEHB, (3) PEHB + 20%NACP; (4) PEHB + 30%NACP; (5) PEHB + 20%NACP+3%MPC; (6) PEHB + 30%NACP+3%MPC. Dentin shear bond strength, Ca/P ion release, recharge and re-release, and protein adsorption were measured. A microcosm biofilm model was tested for lactic-acid production and colony-forming units (CFU). Adding NACP + MPC did not negatively affect dentin bond strength (p > 0.1). With increasing the number of recharge/re-release cycles, the Ca/P ion re-release reached similarly higher levels (p > 0.1), indicating long-term remineralization capability. One recharge enabled the adhesives to have continued re-releases for 21 days. Incorporation of 3% MPC yielded 10-fold decrease in protein adsorption, and 1-2 log decrease in biofilm CFU. The new rechargeable ad...Continue Reading

Citations

Aug 6, 2020·Journal of Functional Biomaterials·Leopoldo Torres, Diane R Bienek
Aug 8, 2019·Dental Materials : Official Publication of the Academy of Dental Materials·Bashayer H BarasHockin H K Xu
Jun 13, 2020·Dental Materials : Official Publication of the Academy of Dental Materials·Abdulrahman A BalhaddadMary Anne S Melo
Apr 21, 2021·Stomatologii︠a︡·A V Blinova, V A Rumyantsev
Jun 11, 2021·Clinical Oral Investigations·Faisal Al-QarniHockin H K Xu

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