Protein-resistant polyurethane prepared by surface-initiated atom transfer radical graft polymerization (ATRgP) of water-soluble polymers: effects of main chain and side chain lengths of grafts

Colloids and Surfaces. B, Biointerfaces
Zhilin JinJ L Brash

Abstract

Water-soluble poly(oligo(ethylene glycol) methacrylate) (poly(OEGMA)) with various main chain and side chain lengths were grafted to polyurethane (PU) surface by surface-initiated atom transfer radical graft polymerization (s-ATRgP). The polymer main chain length was varied by varying the molar ratio of monomer to free initiator in solution (typically 5:1, 50:1, 100:1). Three different side chain lengths were obtained using different OEGMA monomers (MW 300, 475, 1100 g/mol). Water contact angle and X-ray photoelectron spectroscopy (XPS) were used to characterize the modified PU surfaces. The respective effects of poly(OEGMA) main chain and side chain lengths on fibrinogen (Fg) and lysozyme (Lys) adsorption were investigated in single protein systems at room temperature in TBS, pH 7.4. The poly(OEGMA)-grafted PU surfaces were found to be highly protein-resistant, with reductions of Fg and Lys adsorption in the range of 84-98% and 67-91%, respectively, compared to the unmodified PU surface. The adsorption of both proteins decreased with increasing poly(OEGMA) main chain length for a given side chain length (number of EO units). For a given main chain length, the Fg adsorption level did not change significantly with increasing sid...Continue Reading

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Citations

Apr 19, 2012·Colloids and Surfaces. B, Biointerfaces·Zhaoqiang WuHong Chen
Feb 9, 2010·Biomaterials·Johan G AlauzunHeather D Sheardown
Aug 24, 2010·Journal of Biomedical Materials Research. Part a·Irina FundeanuHenk J Busscher
Mar 31, 2015·Analytical and Bioanalytical Chemistry·Hana VaisocherováJiří Homola
Sep 2, 2020·Biointerphases·Alysha SpadaforaHeather Sheardown
Jan 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dicky PranantyoSerena Lay-Ming Teo

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