Protein restriction during pregnancy affects maternal liver lipid metabolism and fetal brain lipid composition in the rat.

American Journal of Physiology. Endocrinology and Metabolism
Nimbe TorresE Zambrano

Abstract

Suboptimal developmental environments program offspring to lifelong metabolic problems. The aim of this study was to determine the impact of protein restriction in pregnancy on maternal liver lipid metabolism at 19 days of gestation (dG) and its effect on fetal brain development. Control (C) and restricted (R) mothers were fed with isocaloric diets containing 20 and 10% of casein. At 19 dG, maternal blood and livers and fetal livers and brains were collected. Serum insulin and leptin levels were determinate in mothers. Maternal and fetal liver lipid and fetal brain lipid quantification were performed. Maternal liver and fetal brain fatty acids were quantified by gas chromatography. In mothers, liver desaturase and elongase mRNAs were measured by RT-PCR. Maternal body and liver weights were similar in both groups. However, fat body composition, including liver lipids, was lower in R mothers. A higher fasting insulin at 19 dG in the R group was observed (C = 0.2 +/- 0.04 vs. R = 0.9 +/- 0.16 ng/ml, P < 0.01) and was inversely related to early growth retardation. Serum leptin in R mothers was significantly higher than that observed in C rats (C = 5 +/- 0.1 vs. R = 7 +/- 0.7 ng/ml, P < 0.05). In addition, protein restriction signif...Continue Reading

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Citations

Mar 16, 2012·Reviews in Endocrine & Metabolic Disorders·Satish C Kalhan, Susan E Marczewski
Nov 27, 2015·The British Journal of Nutrition·C J BautistaE Zambrano
Jan 14, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J S RodriguezE Zambrano
Oct 26, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L A Reyes-CastroE Zambrano
Apr 11, 2015·Journal of Developmental Origins of Health and Disease·C J BautistaE Zambrano
Sep 21, 2013·Molecular and Cellular Endocrinology·Elena ZambranoPeter W Nathanielsz
Jun 12, 2016·Physiology & Behavior·Damien S HunterKathryn L Gatford
Nov 17, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L A Reyes-CastroE Zambrano
Jun 27, 2018·Proceedings of the National Academy of Sciences of the United States of America·Joanna M GouldSandrine Willaime-Morawek
Jun 3, 2021·Children·Rachael M TaylorClare E Collins
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Oswaldo Frausto-GonzálezMaría Eva González-Trujano
Sep 23, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Begoña ZapateríaMaría Pilar Ramos-Álvarez
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