Protein restriction in pregnancy is associated with increased apoptosis of mesenchymal cells at the start of rat metanephrogenesis

Kidney International
Simon J M WelhamAdrian S Woolf

Abstract

In rats, offspring born to mothers supplied low protein diets during pregnancy have fewer glomeruli than normal. We hypothesized that such nephron deficits are associated with altered cell turnover in the metanephros, the embryonic precursor of the adult kidney. Wistar rats were supplied with one of three isocaloric diets from day 0 of pregnancy: control (18% protein) or low protein (9% or 6%) diets. All had a normal chow after birth. Groups were compared by multilevel statistical modeling. At two weeks postnatally, when nephrogenesis has finished, controls had 16.8 x 103 +/- 0.7 x 10(3) (mean +/- SEM) glomeruli/kidney, whereas offspring exposed to 9% diet had 5.1 x 10(3) +/- 1.2 x 10(3) fewer and those exposed to 6% diet had 6.9 x 10(3) +/- 1.7 x 10(3) fewer glomeruli/kidney (P < 0.001, both diets). At embryonic day 13 (E13), when the metanephros has just formed, control metanephroi contained 2.35 x 10(4) +/- 0.15 x 10(4) cells, with no significant differences in low protein groups. At E15, when mesenchyme begins forming primitive nephrons but glomeruli are still absent, controls had 2.00 x 10(6) +/- 0.13 x 10(6) cells. E15 embryos exposed to 9% protein had 1.09 x 10(6) +/- 0.36 x 10(6) fewer cells/metanephros than controls, w...Continue Reading

References

Dec 1, 1992·The Journal of Cell Biology·C KosekiQ al-Awqati
Apr 2, 1987·Nature·R BravoH Macdonald-Bravo
Oct 1, 1988·American Journal of Hypertension·B M BrennerS Anderson
Apr 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·C Merlet-BénichouB Leroy
May 1, 1993·Pediatric Pathology·S A HinchliffeD van Velzen
Jan 1, 1996·Kidney International·P J WinyardA S Woolf
Nov 28, 1997·Differentiation; Research in Biological Diversity·E KitrakiF Stylianopoulou
Aug 11, 1998·Journal of the American Society of Nephrology : JASN·A FassiA Remuzzi
Dec 9, 1998·Kidney International·M Lelièvre-PégorierC Merlet-Bénichou
May 1, 1999·Experimental Cell Research·T ArakiM Miura
Sep 12, 2000·The American Journal of Pathology·E TorbanP R Goodyer
Jan 3, 2001·Kidney International·V M VehaskariJ Manning
Apr 24, 2001·Journal of the American Society of Nephrology : JASN·Takehiko MiyajiAkira Hishida
May 17, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S E JonesS M Marshall

❮ Previous
Next ❯

Citations

Sep 13, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·John MakrakisM Jane Black
Jul 16, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Henriqueta D CardosoAna D O Paixão
Oct 13, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Umberto SimeoniFarid Boubred
Mar 23, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Georgiy R KhodusAnita Aperia
May 25, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Leucio D Vieira-FilhoAna D O Paixão
Mar 21, 2012·Reviews in Endocrine & Metabolic Disorders·Malgorzata S Martin-Gronert, Susan E Ozanne
Oct 9, 2002·Trends in Endocrinology and Metabolism : TEM·Miodrag DodicE Marelyn Wintour
Feb 1, 2010·Journal of Developmental Origins of Health and Disease·J A JolesS C Langley-Evans
Aug 1, 2010·Journal of Developmental Origins of Health and Disease·W E HoyJ F Bertram
Aug 1, 2011·Journal of Developmental Origins of Health and Disease·S A TaftiT R Magee
Oct 27, 2010·Nature Communications·Juan LiAnita Aperia
May 1, 2008·Nature Clinical Practice. Nephrology·Larissa KerecukAdrian S Woolf
Dec 20, 2002·Journal of Anatomy·Jonathan G D Foley, Jonathan B L Bard
Sep 3, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Simon J M Welham
Jun 17, 2004·Current Opinion in Nephrology and Hypertension·Julie R Ingelfinger
May 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K A BrennanD M Olson
Jul 14, 2006·Kidney & Blood Pressure Research·Michiel SchreuderAns van Wijk
Apr 5, 2013·PloS One·Corina AndersAdrian S Woolf
May 14, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Marija Daković-BjelakovićDejan Mitić
Feb 8, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·K A BrennanM E Symonds
Feb 4, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jennifer R CharltonJ Bryan Carmody
Jan 30, 2004·The British Journal of Nutrition·Sarah McMullenSimon C Langley-Evans
Apr 26, 2003·Archives of Physiology and Biochemistry·S C Langley-EvansM C Marchand
Apr 26, 2003·Archives of Physiology and Biochemistry·J Schwartz, K L Thornburg
Oct 18, 2015·Clinical and Experimental Pharmacology & Physiology·V F I RichterD H Hryciw
Aug 21, 2012·The Journal of Urology·Wenjie WeiEdward J Macarak
Dec 18, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Huanling YuRong Xiao
Jul 21, 2009·Seminars in Nephrology·Carolyn L Abitbol, Julie R Ingelfinger
Mar 13, 2008·Advances in Chronic Kidney Disease·Julie R Ingelfinger
Nov 13, 2007·Seminars in Fetal & Neonatal Medicine·Adrian S Woolf

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physiological Genomics
Simon J M WelhamAdrian S Woolf
Translational Research : the Journal of Laboratory and Clinical Medicine
Cary StellohAsraf El-Meanawy
Journal of the American Society of Nephrology : JASN
Katalin Susztak
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Maria M RodriguezGastón Zilleruelo
© 2022 Meta ULC. All rights reserved